PLUTONIUM, RADIOACTIVE: Nuclear Power Plant Emissions

Sediment/Soil Concentrations :
SEDIMENT: Plutonium-239 and plutonium-240 cannot be distinguished by alpha spectroscopy and are usually reported together(1). Plutonium concentrations in soils/sediment at 91 waste sites at 18 US Department of Energy facilities ranged from 0.00011 to 3.5X10+6 pCi/kg(2). Plutonium concentrations were measured in various environmental matrices collected from Antarctica at the Ross Sea region surrounding the Italian Terra Nova Base in 1989-96(3). Mean plutonium-239+plutonium-240 concentrations ranged from 0.005-0.0969 and <0.0003-0.0806 Bq/kg in lacustrine and marine sediment, respectively(3). Mean plutonium-238 concentrations ranged from 0.0018-0.0199 and <0.0003-0.0125 Bq/kg in lacustrine (wetland associated with a lake) and marine sediment, respectively(3). The British Nuclear Fuels Ltd nuclear fuel reprocessing plants at Sellafield in Cumbria, UK discharge low level radioactive waste into the Irish Sea(4). Plutonium-239+plutonium-240 concentrations in sediment cores samples collected in October 1994 from 9 sites around the intertidal area of the Irish Sea, UK ranged from 2.98 to 265 Bq/kg(4). Plutonium-239+plutonium-240 concentrations in bottom sediments form the Fram Strait in the Arctic ranged from not detected to 2.264 Bq/kg(5). There are 4 nuclear power plants and one research institute with two small nuclear reactors along the river Elbe in Germany(6). Plutonium-238 and plutonium-239+plutonium-240 concentrations in sediments collected between 1986-88 from the river Elbe ranged from 22-39 and 159-181 mBq/kg, respectively(6). Plutonium-239+plutonium-240 concentrations in sediment cores from Sagami Bay of the coast of Japan margin ranged from 0.94-2.89, 2.11-11.17, and 0.023-3.82 mBq/g dry weight in samples from Tokyo Canyon, Sagami Nada, and Sagami Trough, respectively(7).
[(1) Eisenbud M, Gesell T, eds; Environmental radioactivity. 4th ed. San Diego, CA: Academic Press. pp. 310-311 (1997) (2) Riley RG, Zachara JM; Chemical Contaminants on DOE Lands and Selection of Contaminant Mixtures for Subsurface Science Research. U.S. Dept Energy, Off Energy Res, Subsurface Science Prog, Washington, DC. DOE/ER-0547T DE92014826, 77 pp. (1992) (3) Jia G et al; Biol Trace Elem Res 71-72: 349-57 (1999) (4) Kuwabara J et al; J Radioanal Nucl Chem 240: 593-601 (1999) (5) Masque P et al; Environ Sci Technol 37: 4848-54 (2003) (6) Wilken RD, Diehl R; pp. 295-200 in Coastal and Estuarine Studies. Michaelis W, ed. Springer-Verlag: Berlin Heidelberg (1990) (7) Zheng J, Yamada M; Environ Sci Technol 38: 3498-504 (2004) ]**PEER REVIEWED**


Environmental Water Concentrations :
SURFACE WATER: Plutonium-239 and plutonium-240 cannot be distinguished by alpha spectroscopy and are usually reported together(1). Plutonium-239+plutonium-240 concentrations in filtered sea water from the Spanish Mediterranean coast averaged 12 mBq/cu m(2). The mean plutonium-239+plutonium-240 concentration in the particulate fraction was 1.5 mBq/cu m(2). The Savannah River Plant, the principal plutonium production facility in for the US Department of Energy, is located about 256 km upstream from the mouth of the Savannah River(3). Plutonium-238 concentrations in the Savannah River Estuary ranged from 0.4 to 1.9 uBq/L and 26 to 100 mBq/kg in the dissolved phase and in suspended particulate, respectively(3). Plutonium-239+plutonium-240 concentrations ranged from 1.9 to 5.2 uBq/L and 235 to 665 mBq/kg in the dissolved phase and in suspended particulate, respectively(3). There are 4 nuclear power plants and one research institute with two small nuclear reactors along the river Elbe in Germany(4). Plutonium-238 and plutonium-239+plutonium-240 concentrations water collected between 1985-88 from the river Elbe ranged from 0.007-0.05 and 0.03-0.16 mBq/L, respectively(4).
[(1) Eisenbud M, Gesell T, eds; Environmental radioactivity. 4th ed. San Diego, CA: Academic Press. pp. 310-311 (1997) (2) Molero J et al; J Environ Radiat 28: 271-83 (1995) (3) Olsen CR et al; Environ Sci Technol 23: 1475-81 (1989) (4) Wilken RD, Diehl R; pp. 295-300 in Coastal and Estuarine Studies. Michaelis W, ed. Springer-Verlag: Berlin Heidelberg (1990) ]**PEER REVIEWED**


Fish/Seafood Concentrations :
Plutonium-239 and plutonium-240 cannot be distinguished by alpha spectroscopy and are usually reported together(1). Plutonium-239+plutonium-240 concentrations in mussels collected in 1977 and 1978 from Bodega Head, CA and from Narragansett Bay, RI ranged from 1.9 to 4.6 and 0.3 to 2.1 disintegrations per minute per kg dry weight, respectively(2). There are 4 nuclear power plants and one research institute with two small nuclear reactors along the river Elbe in Germany(3). Plutonium-238 and plutonium-239+plutonium-240 was not detected (<0.1 mBq/kg) in fish collected from the river Elbe(3).
[(1) Eisenbud M, Gesell T, eds; Environmental radioactivity. 4th ed. San Diego, CA: Academic Press. pp. 310-311 (1997) (2) Goldberg ED; Environ Monit Assess 7: 91-103 (1986) (3) Wilken RD, Diehl R; pp. 295-200 in Coastal and Estuarine Studies. Michaelis W, ed. Springer-Verlag: Berlin Heidelberg (1990) ]**PEER REVIEWED**


Methods of Manufacturing :
In the past, most plutonium in DOE facilities was produced for nuclear weapons and was composed of greater than 90 wt% plutonium-239 and about 6 to 8 wt% plutonium-240. This material has been referred to as weapons grade or low exposure plutonium. It is produced on a large scale by irradiating uranium-238 in moderated production reactors. Plutonium has also been produced as a byproduct in the operation of research reactors, and commercial nuclear power plants. It is recovered and purified by solvent extraction and ion exchange processes. The resulting highly concentrated Pu(NO3)4 product solution is converted to a nonhygroscopic PuF4 intermediate by one of several processes before being reduced to metal with calcium. Plutonium is also produced from the waste streams of the conversion processes and scrap recovery operations, which include material from research and development efforts. Other processes for reduction to metal include direct reduction of the oxide and electrolytic reduction.
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. p 2-1 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Sediment/Soil Concentrations :
SEDIMENT: Plutonium-239+plutonium240, plutonium-238, plutonium-241 concentrations were measured in intertidal sediment from the Irish Sea; concentrations ranged from for 2.3-1,804, 0.32-34.7, and 218-37,884 Bq/kg dry weight, respectively(1). Plutonium-238 and plutonium-239-plutonium-240 concentrations in surface sediments from the Mediterranean Sea near the Vandellos Nuclear Power Plant collected in 1989 ranged from 0.22-0.80 and 8.2-12.6 Bq/kg, respectively(2).
[(1) Assinder DJ et al; J Radioanal Nucl Chem 170: 333-46 (1993) (2) Sanchez-Cabeza JA, Molero J; J Environ Radioact 51: 211-28 (2000) ]**PEER REVIEWED**


Effluent Concentrations :
Among the major effluents from the use and processing of nuclear fuel are ... plutonium. ... Of these, only tritium and plutonium can possibly enter water supplies. The predominant form of plutonium release from nuclear power and processing plants is as an aerosol that will have little or no impact on drinking water. Although a single incident has occurred in which as much as 18,750 Ci of plutonium were released from liquid storage on a local basis, none apparently reached off site water supplies. The usual rate of release from liquid storage at a controlled sites is about 1 mCi/yr.
[National Research Council. Drinking Water & Health Volume 1. Washington, DC: National Academy Press, 1977., p. 865]**PEER REVIEWED**


General Manufacturing Information :
.. ca. 400 tons of plutonium has been produced in nuclear power stations outside centrally planned economies (i.e. excluding the former Eastern-bloc countries).
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present., p. VA21: 133 (1992)]**PEER REVIEWED**


Major Uses :
Because of its high specific alpha activity and high decay heat, plutonium-238 has been used as an isotopic heat source for devices that generate thermoelectric power, such as the Space Nuclear Auxiliary Power (SNAP) systems used in lunar and deep space missions. /Plutonium-238/
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. p 2-1 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Disposal Methods :
/SRP/ Wastes in the Waste Isolation Pilot Plant (WIPP) are from the nuclear weapons industry (plutonium) - research and development. For a waste to be accepted at WIPP it must be a transuranic "TRU" waste and: (1) </= 100 nanoCi/gram, (2) an alpha emitting transuranium isotope with atomic number greater than uranium, and (3) have a half life greater than 20 years. The wastes must be handled remotely if they produce >/= 200 millirems/hr; if less, they can be contact handled.
**PEER REVIEWED**


Human Toxicity Excerpts :
/EPIDEMIOLOGY STUDIES/ A major study was performed on all 14,319 workers (11,635 men) employed at the Sellafield fuel reprocessing plant of British Nuclear Fuels between 1947 and 1975 ... The mortality of these workers was studied up to the end of 1992, and cancer incidence was examined from 1971 through 1986. The study included 5,203 workers who were monitored for exposure to plutonium, of whom 4,609 were assessed for dose. The body burden of most workers was estimated to be < 50 Bq, and only a few had > 1 kBq. ... (In this cohort, the average cumulative doses from plutonium were 712 mSv to bone surfaces, 194 mSv to lung, 91 mSv to liver, and 58 mSv to red bone marrow ... ). The number of deaths /and death rates/ from all cancers in plutonium workers is not excessive ... . The numbers of deaths from cancers of the liver, lung, and bone were not in excess, but there were significant excesses of deaths among plutonium workers when compared with the rates in England and Wales from cancer of the pleura (SMR, 4.71; p < 0.001), breast cancer (SMR, 2.36; p < 0.05) and cancers of ill-defined and secondary sites (SMR, 1.44; p < 0.05). /Plutonium, NOS/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 188-91 (2001)]**PEER REVIEWED**


Environmental Water Concentrations :
GROUNDWATER: Plutonium-239 and plutonium-240 cannot be distinguished by alpha spectroscopy and are usually reported together(1). Plutonium-239+plutonium240 concentrations were measured in monitoring wells in a small aquifer in the Mortandad Canyon, which receives liquid wastes from the Los Alamos National Laboratory, NM in 1982 and 1983(2). Plutonium-239+plutonium-240 was detectable in monitoring wells up to 3,390 meters downgradient from the discharge; decreasing from 1,400 to 0.55 mBq/L between the first and last monitoring well(2). Plutonium concentrations in groundwater at 91 waste sites at 18 US Department of Energy facilities ranged from 0.0009 to 12.8 pCi/L(3). Plutonium-239+plutonium-240 concentrations in porewater collected over a year from an inter-tidal salt marsh in the Esk Estuary, West Cumbria, UK near the British Nuclear Fuel Ltd Sellafield nuclear fuel reprocessing plant ranged from 0.84 mBq/L in August to 3.21 mBq/L in April(4).
[(1) Eisenbud M, Gesell T, eds; Environmental radioactivity. 4th ed. San Diego, CA: Academic Press. pp. 310-311 (1997) (2) Penrose WR et al; Environ Sci Technol 24: 228-34 (1990) (3)Riley RG, Zachara JM; Chemical Contaminants on DOE Lands and Selection of Contaminant Mixtures for Subsurface Science Research. U.S. Dept. Energy, Off Energy Res, Subsurface Science Prog, Washington, DC. DOE/ER-0547T DE92014826, 77 pp. (1992) (4) Keith-Roach MJ et al; Environ Sci Technol 34: 4273-7 (2000) ]**PEER REVIEWED**


Ecotoxicity Excerpts :
/FIELD STUDIES/ Activity concentrations of radionuclides (cesium-134, cesium-137, plutonium-238, plutonium-239,- 240 and americium-241) were measured in vegetation, invertebrates and wood mice, Apodemus sylvaticus, collected in Lady Wood, a coniferous woodland in the vicinity of the British Nuclear Fuels reprocessing plant at Sellafield, Cumbria, UK. Vegetation was of low diversity and biomass with activity concentrations ranging from 1 to 5 Bq kg-1 (cesium-134), 0.3-0.5 Bq kg-1 (plutonium-238), 0.8-8 Bq kg-1 (plutonium-239 + 240), and 0.6-16 Bq kg-1 (americium-241), dry wt. Cesium-137 activity concentrations were high compared to the reference site in Cheshire, varying between 65 and 280 Bq kg-1. Marked inter-specific and temporal differences in radionuclide activity concentrations were recorded for invertebrate populations. Cesium-137, plutonium-238, plutonium-239,-240 and americium-241 activity concentrations in detritivorous invertebrates were consistently higher than in all other invertebrate groups reflecting contamination of the leaf litter. The activity concentrations in detritivores increased during the autumn and winter, reflecting changes in diet as food sources varied throughout the year. Activity concentrations in invertebrates caught in Lady Wood were generally an order of magnitude higher than for the reference site. Activity concentrations in wood mice varied between 7 and 150 Bq kg-1 (cesium-137), 0.1-0.3 Bq kg-1 (plutonium-238), 0.1-0.6 Bq kg-1 (plutoniuim-239,-240) and 0.2-0.4 Bq kg-1 (americium-241). There were clear differences in the activity concentration of cesium-137 (P < 0.01), plutonium-239 + 240 (P < 0.05) and americium-241 (P < 0.05) in animals caught in Lady Wood compared to the reference site. However, the activity concentrations for plutonium-238 were similar at both sites, reflecting a low gastrointestinal transfer. Seasonal variation in activity concentrations was observed for cesium-137, plutonium-238 and americium-241. This variation is attributed to changes in the age structure of the population and diet throughout the year. /Plutonium-238, Plutonium-239,-240/
[Copplestone D et al; Sci Total Environ 239 (1-3): 95-109 (1999) ]**PEER REVIEWED** PubMed Abstract


Absorption, Distribution & Excretion :
Ingestion: The fractional absorption of plutonium-244 administered in citrate solution with a midday meal to three volunteers was in the range 3x10-4 to 9x10-4. Measurements on two further volunteers increased the range to 1x10-4 to 1x10-3, with an average of 6x10-4. In volunteers who ate winkles collected on the Cumbrian coast near to the nuclear-fuel reprocessing plant at Sellafield, the average fractional absorption of plutonium was 1.7x10-4, with a range of 2x10-5 to 5x10-4. The fractional absorption from the gut of fall-out plutonium in reindeer meat ... was estimated to be 8x10-4, but the estimate is uncertain. /Plutonium-244 citrate/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 356 (2001)]**PEER REVIEWED**


Human Toxicity Excerpts :
/EPIDEMIOLOGY STUDIES/ A cohort of about 21,000 Russian nuclear workers who worked at the Mayak plutonium production complex between 1948 and 1972 is under study. The Mayak complex, which is located in the Chelyabinsk region of the Russian Federation, includes three main plants; a reactor complex, a radiochemical separation plant, and a plutonium production plant. Workers at all three plants had potential for exposure to external radiation, and workers at the radiochemical and plutonium production plants also had potential for exposure to plutonium. Recently, data on workers at two auxiliary plants, who had much less potential for exposure, have been added to the cohort under study to expand the comparison group. As is the case for other nuclear worker cohorts, estimates of annual external doses are available from individual film badge monitoring data. Some workers were also monitored for plutonium exposure; however, since routine testing based on large urine samples did not begin until about 1970, only about 40% of workers with potential for such exposure have been monitored. External exposure and exposure to plutonium for Mayak workers far exceed those of other nuclear worker cohorts discussed previously... . For example, for the nearly 11,000 monitored workers hired before 1959, the mean cumulative external dose was 1.2 Gy, more than an order of magnitude higher than any of the cohorts described /previously/... . Analyses focused on leukemia (excluding chronic lymphocytic leukemia); cancers of the lung, liver, and bone (analyzed as a group); and solid cancers excluding lung, liver, and bone cancers (also analyzed as a group). The lung, liver and bone are the organs that receive the largest doses from plutonium, and excess cancers in all three organs have been clearly linked to plutonium exposure among Mayak workers. Analyses were adjusted for internal exposure from plutonium by using the estimated body burden for workers who had plutonium-monitoring data and by using a plutonium surrogate variable for workers who were not monitored for plutonium. The plutonium surrogate variable was recently developed from detailed work histories. For leukemia, the estimated /excess risk ratio/ (ERR)/Gy was 6.9 (90% CI 2.9, 15) for the period 3-5 years after exposure and 0.5 (90% CI 0.1, 1.1) for the period 5 or more years after exposure. The estimate based on the entire period was 1.0 (90% CI 0.5, 2.0). There were no statistically significant departures from linearity and no evidence of modification by sex or age at hire. Estimates for the solid cancer endpoints are /as follows:/ lung, liver or bone (linear model) ERR/Sv 0.30 (90% CI 0.18, 0.46); other solid cancers (linear model) ERR/Sv 0.08 (90% CI 0.03, 0.14); all solid cancers (linear model) ERR/Sv 0.15 (90% CI 0.09, 0.20); lung, liver, or bone (linear-quadratic model) ERR/Sv 0.54 (90% CI 0.27, 0.89); other solid cancers (linear-quadratic model) ERR/Sv 0.21 (90% CI 0.06, 0.37); all solid cancers (linear-quadratic model) ERR/Sv 0.30 (90% CI 0.18, 0.43). /from table/ /Plutonium, NOS/
[NAS/BRER; Health Risks from Exposure to Low Levels of Ionizing Radiation BEIR VII- Phase 2. p. 357 (2005) ]**PEER REVIEWED**


Major Uses :
Of the 15 plutonium isotopes, the two that have proven most useful are masses 239 and 238. Plutonium-239 is fissile, i.e., atoms of plutonium split upon exposure to thermal or fast neutrons. Chemical reactions can release a few electron volts of energy per atom; however, when a plutonium nucleus splits, it releases about 200 MeV of energy and two or three neutrons. This release of energy makes plutonium-239 useful for nuclear weapons and reactor fuel. In fact, in light water reactors (LWRs) much of the power originates from the fission of plutonium-239, which is produced by neutron capture in uranium-238. /Plutonium isotopes/
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. P 2-6 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Major Uses :
Uses of Plutonium Isotopes: Plutonium-236, plutonium-237. Popular environmental and biological chemical tracers. Both available in microcurie quantities. Plutonium-238. Small thermal and electric-power generators. Available in various isotopic enrichments, ranging from 78% to 99+%. Plutonium-239. Nuclear weapons and as a fast reactor fuel. Also, frequently used in chemical research where production-grade material of mixed isotopic content is suitable. Available enrichments range from 97% to 99.99+%. Plutonium-240. Principally in flux monitors for fast reactors. Available enrichments range from 93% to 99+%. Plutonium-241. The parent from which high-assay americium-241 can be isolated for industrial purposes. Samples available in enrichments of 93%. Plutonium-242. For study of the physical properties of plutonium; also as a mass spectroscopy tracer and standard. Samples available in enrichments ranging from 95% to 99.9+%; enrichments of production-grade material range from 85% to 95%. Plutonium-244. Currently, the only isotope available as a National Institute of Standards and Technology (NIST) Standard Reference Material (SRM). /From table/ /Plutonium isotopes/
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. P 2-5 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Artificial Pollution Sources :
Plutonium may be released to the environment by nuclear weapons testing, accidents involving weapons transport, nuclear reactors, radioisotope generators, fuel processing and reprocessing, and fuel transport(1). Atmospheric nuclear weapons testing is the main source of plutonium in the environment, and is the largest source of plutonium-239 and plutonium-240 in the environment(1). An estimated 1.3X10+16 Bq of plutonium-239+plutonium-240 have been released to the environment from atmospheric detonation of nuclear weapons(2). An estimated 7.9X10+14 Bq of plutonium-238 has been released, mostly from the burn-up of the nuclear powered satellite SNAP-9(2). An estimated 3.7X10+13 Bq of plutonium-239+plutonium-240 was released from the Chernobyl accident(2). Between 1954 and 1974 approximately 1.4X10+11 and 1.1X10+10 Bq of plutonium have been released into the atmosphere and surface waters, respectively, from fuel reprocessing operations at the Savannah River Plant, the principal plutonium production facility for the US Department of Energy(3). Plutonium was first discovered in 1940(2). Plutonium isotopes with mass numbers 232-246 have been identified and all are radioactive(2). Plutonium-239 is the most important isotope, as well as plutonium-238, plutonium-242, and plutonium-244(2). Plutonium forms compounds with many metallic elements and all of the nonmetallic elements, except those of the noble gas group(2).
[(1) ATSDR; Toxicological Profile for Plutonium. December 1990. Dept Hlth Human Serv., Public Hlth Service, Agency for Toxic Substances and Disease Registry pp. 87-106 (1990) (2) Morss LR; in Kirk-Othmer Encycl Chem Technol. Kroschwitz JI, ed. 4th ed. NY, NY: John Wiley & Sons 19: 407-43 (1996) (3) Olsen CR et al; Environ Sci Technol 23: 1475-81 (1989) ]**PEER REVIEWED**


Methods of Manufacturing :
Plutonium is produced in nuclear reactors from uranium-238 that absorbs neutrons emitted by the fission of uranium-235, which is a naturally occurring uranium isotope found with uranium-238. Uranium-239 is formed and emits a beta particle to form neptunium-239 that decays by beta emission to form plutonium-239. Once started, the process is spontaneous until the uranium fuel rods become a specific uranium-plutonium mixture. The rods are dissolved in acid, and plutonium is separated primarily by solvent extraction, finally producing a concentrated plutonium solution. Pure plutonium metal can be prepared by precipitating plutonium peroxide or oxalate, igniting the precipitate to PuO2, converting the oxide to PuF3, and reducing Pu+3 to the metal in an ignited mixture containing metallic calcium. /Plutonium/
[Multi-Agency Radiological Laboratory Analytical Protocols Manual Volume II: Chapters 10-17 and Appendix F. (July 2004) p 14-138 NUREG-1576, EPA 402-B-04-001B, NTIS PB2004-105421. Available at http://www.nrc.gov/reading-rm/doc-collections/nuregs/staff/sr1576/sr1576v2.pdf as of October 12, 2006 ]**PEER REVIEWED**


Preventive Measures :
In a nuclear weapon accident involving fire or conventional explosion, most of the radiation dose received by people in the immediate vicinity would result from inhalation of plutonium-239. This is accompanied by the nuclide americium-241, which is much easier to determine by external counting because of the 60 keV gamma ray emission. In the event of an accident, a priority would be to identify any people who have had intakes of plutonium-239 which were so large that decorporation therapy should be considered. Direct measurement of lung content provides the most rapid and convenient method for assessing intakes by inhalation. A transportable system has been considered as this could be deployed close to the site of the accident and would allow rapid measurements to be made. The feasibility of a transportable americium-241-in-nose-blow and nasal swab measurement system has also been considered. This would be used to help select people for americium-241-in-lung measurements.
[Youngman MJ et al; Radiat Prot Dosimetry 105 (1-4): 473-6 (2003) ]**PEER REVIEWED** PubMed Abstract


Methods of Manufacturing :
High-exposure plutonium, i.e., plutonium containing significant fractions of plutonium-240, plutonium-241, and plutonium-242, is produced in power reactor fuels. ... Reactor-produced plutonium goes through several different chemical processes before it becomes a solid metal. Irradiated nuclear fuel elements are dissolved in strong acid and the plutonium is chemically extracted from the solution. ... The solution is put through another processing stage that converts it from a liquid to a powder. ... The powder is then placed in a crucible mold and heated without melting until it becomes a solid metal.
[U.S. Department of Energy; DOE Standard. Radiological Safety Training for Plutonium Facilities. Instructors Manual. p 2-4, 5-6 DOE-HDBK-1145-2001 (2001) ]**PEER REVIEWED**


Mechanism of Action :
Lung cancer from radon or plutonium-239 exposure has been linked to alpha-particles that damage DNA through large deletions and point mutations. /The authors/ investigated the involvement of an epigenetic mechanism, gene inactivation by promoter hypermethylation in adenocarcinomas from plutonium-exposed workers at MAYAK, the first Russian nuclear enterprise established to manufacture weapons plutonium. Adenocarcinomas were collected retrospectively from 71 workers and 69 non-worker controls. Lung adenocarcinomas were examined from workers and non-worker controls for methylation of the CDKN2A (p16), O(6)-methylguanine-DNA methyltransferase (MGMT), death associated protein kinase (DAP-K), and Ras effector homolog 1 genes (RASSF1A). The prevalence for methylation of the MGMT or DAP-K genes did not differ between workers and controls, while a higher prevalence for methylation of the RASSF1A gene was seen in tumors from controls. In marked contrast, the prevalence for methylation of p16, a key regulator of the cell cycle, was increased significantly (P = 0.03) in tumors from workers compared with non-worker controls. Stratification of plutonium exposure into tertiles also revealed a striking dose response for methylation of the p16 gene (P = 0.008). Workers in the plutonium plant where exposure to internal radiation was highest had a 3.5 times (C.I. 1.5, 8.5; P = 0.001) greater risk for p16 methylation in their tumors than controls. This increased probability for methylation approximated the 4-fold increase in relative risk for adenocarcinoma in this group of workers exposed to plutonium. In addition, a trend (P = 0.08) was seen for an increase in the number of genes methylated (> or =2 genes) with plutonium dose. Here /the authors/ demonstrate that exposure to plutonium may elevate the risk for adenocarcinoma through specifically targeting the p16 gene for inactivation by promoter methylation. /Plutonium-239/
[Belinsky SA et al; Carcinogenesis 25 (6): 1063-7 (2004) ]**PEER REVIEWED** PubMed Abstract


Other Chemical/Physical Properties :
DECAY PATHWAY: Plutonium-236, half-life 2.851 years, decays via alpha emission, 5867 keV (69.3% 5767.7 keV; 30.6% 5721.0 keV) to uranium-232, half-life 68.9 years; decays via alpha emission, 5414 keV (68.2% 5320.1 keV; 31.6% 5263.4 keV) to thorium-228, half-life 1.9116 years; decays via alpha emission, 5520 keV (72.2% 5423.2 keV; 27.2% 5340.4 keV) to radium-224, half-life 3.66 days; decays via alpha emission, 5789 keV (94.9% 5685.4 keV; 5.06% 5448.6 keV) to radon-220, half-life 55.6 seconds; decays via alpha emission, 99.9% 6405 keV, to polonium-216, half-life 0.145 seconds; decays via alpha emission, 99.998% 6778.3 keV, to lead-212, half-life 10.64 hours; decays via beta(-) emission (82.5% 335 keV maximum, 94.8 average energy; 12.3% 173.1 keV average energy)and gamma emission (abs intensity: 100% 238.6 keV) to bismuth-212, half-life 60.55 minutes; 64.06% of bismuth-212 decays via beta (-) emission (86.6%, 832.5 average energy; 6.81%, 531.5 keV average energy) to polonium-212, half-life 45.1 seconds; 35.94% of bismuth-212 decays via alpha emission, 6207 keV (69.9% 6050.8 keV; 27.1% 6089.9 keV) to thallium-208, half-life 3.053 minutes; polonium-212 decays via alpha emission, 8954 keV (96.9% 11650 keV) to lead-208, half life stable; thallium-208 decays via beta (-) emission (48.7%, 1796.3 keV maximum, 647.4 average energy; 24.5%, 1285.6 keV maximum, 439.6 keV; 21.8%, 1518.9 keV maximum, 533.3 keV average energy) and gamma emission (abs intensities: 85.2% 583.2 keV; 22.8% 510.8 keV; 12.5% 860.6 keV) to lead-208, half-life stable.
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Radiation Limits & Potential :
DECAY PATHWAY: Plutonium-236, half-life 2.851 years, decays via alpha emission, 5867 keV (69.3% 5767.7 keV; 30.6% 5721.0 keV) to uranium-232, half-life 68.9 years; decays via alpha emission, 5414 keV (68.2% 5320.1 keV; 31.6% 5263.4 keV) to thorium-228, half-life 1.9116 years; decays via alpha emission, 5520 keV (72.2% 5423.2 keV; 27.2% 5340.4 keV) to radium-224, half-life 3.66 days; decays via alpha emission, 5789 keV (94.9% 5685.4 keV; 5.06% 5448.6 keV) to radon-220, half-life 55.6 seconds; decays via alpha emission, 99.9% 6405 keV, to polonium-216, half-life 0.145 seconds; decays via alpha emission, 99.998% 6778.3 keV, to lead-212, half-life 10.64 hours; decays via beta(-) emission (82.5% 335 keV maximum, 94.8 average energy; 12.3% 173.1 keV average energy)and gamma emission (abs intensity: 100% 238.6 keV) to bismuth-212, half-life 60.55 minutes; 64.06% of bismuth-212 decays via beta (-) emission (86.6%, 832.5 average energy; 6.81%, 531.5 keV average energy) to polonium-212, half-life 45.1 seconds; 35.94% of bismuth-212 decays via alpha emission, 6207 keV (69.9% 6050.8 keV; 27.1% 6089.9 keV) to thallium-208, half-life 3.053 minutes; polonium-212 decays via alpha emission, 8954 keV (96.9% 11650 keV) to lead-208, half life stable; thallium-208 decays via beta (-) emission (48.7%, 1796.3 keV maximum, 647.4 average energy; 24.5%, 1285.6 keV maximum, 439.6 keV; 21.8%, 1518.9 keV maximum, 533.3 keV average energy) and gamma emission (abs intensities: 85.2% 583.2 keV; 22.8% 510.8 keV; 12.5% 860.6 keV) to lead-208, half-life stable.
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Major Uses :
The half-life of plutonium-238 is short enough (88 years) to create a high heat output and long enough to provide long-term power without replenishment. These characteristics make it an ideal heat source for thermoelectric generators. These generators have been used to power ocean buoys and space satellites where long-term, reliable power is essential. /Plutonium-238/
[U.S. Department of Energy; DOE Standard. Radiological Safety Training for Plutonium Facilities. Instructors Manual. p 4 DOE-HDBK-1145-2001 (2001) ]**PEER REVIEWED**


Other Chemical/Physical Properties :
All plutonium isotopes are radioactive. Isotopes with even mass numbers (except mass number 246) are primarily alpha emitters. Isotopes of mass numbers 232, 233, 234, 235, and 237 also decay by electron capture; isotopes of mass numbers 241, 243, 245, and 246 decay by beta emission. Many of the alpha-emitting isotopes, such as plutonium-238 and plutonium-240, also fission spontaneously and emit neutrons. All of the particle emissions are accompanied by X-ray and gamma-ray emissions over a wide range of energies. /Plutonium isotopes/
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. p 2-6 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Radiation Limits & Potential :
All plutonium isotopes are radioactive. Isotopes with even mass numbers (except mass number 246) are primarily alpha emitters. Isotopes of mass numbers 232, 233, 234, 235, and 237 also decay by electron capture; isotopes of mass numbers 241, 243, 245, and 246 decay by beta emission. Many of the alpha-emitting isotopes, such as plutonium-238 and plutonium-240, also fission spontaneously and emit neutrons. All of the particle emissions are accompanied by X-ray and gamma-ray emissions over a wide range of energies.
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. p 2-6 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Major Uses :
Small amounts of plutonium-238 with low plutonium-236 content were used as a power source for medical prosthetic devices such as cardiac pacemakers and a prototype artificial heart, but lithium batteries have replaced these plutonium power sources. /Plutonium-236 & plutonium-238/
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. p 2-1 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Plant Concentrations :
Most of the plutonium found in field grown native plants and agricultural crops is due to surface contamination rather than soil plant transfer. Plutonium concn depends on plant species, on the type and age and status of vegetation; on the pH; cation exchange capacity; mineral and organic composition of the soil; and on the physical and chemical form of contamination; as well as its duration. The highest uptake of plutonium in cheat grass occurs, for example, when plutonium is present in the soil as the stable citrate complex or as a complex with macromolecules, like humic acid or fulvic acid.
[Seiler, H.G., H. Sigel and A. Sigel (eds.). Handbook on the Toxicity of Inorganic Compounds. New York, NY: Marcel Dekker, Inc. 1988., p. 721]**PEER REVIEWED**


Environmental Fate/Exposure Summary :
Plutonium may be released to the environment by nuclear weapons testing, accidents involving weapons transport, nuclear reactors, radioisotope generators, fuel processing and reprocessing, and fuel transport. Atmospheric nuclear weapons testing is the main source of plutonium in the environment, and is the largest source of plutonium-239 and plutonium-240 in the environment. Plutonium was first discovered in 1940. Plutonium isotopes with mass numbers 232-246 have been identified and all are radioactive. Plutonium-239 is the most important isotope, as well as plutonium-238, plutonium-242, and plutonium-244. Plutonium forms compounds with many metallic elements and all of the nonmetallic elements, except those of the noble gas group. Plutonium occurs in naturally occurring ores in very small amounts; the atom to atom ratio of plutonium to uranium in uranium ores is <1 to 10+11 (e.g., less than one atom of plutonium per 10+11 atoms of uranium). If released to air, plutonium compounds would exist solely in the particulate phase in the ambient atmosphere since they are ionic and would not be volatile. Particulate-phase plutonium compounds will be removed from the atmosphere by wet and dry deposition. Plutonium is generally immobile in soil. Physical processes, such as cultivation of soil, may redistribute plutonium compounds between soil layers. Erosion by wind and water will also transport plutonium compounds found in surface soils through the environment. Plutonium compounds are ionic and will not volatilize from dry or moist soil surfaces. In solution, the Pu(III-VI) oxidation states can exist simultaneously. Plutonium oxidizes rapidly, forming insoluble PuO2, which is the most common form of plutonium in the environment. Plutonium ions can form complex ions with simple hard Lewis bases, such as ligands with oxygen donor groups. Partition coefficients (Kd) ranging from 8X10+4 to 1.5X10+5 were determined for (plutonium-239+plutonium-240) in arctic surface sediments from the Kara Sea. In most natural aquatic systems, plutonium is associated with either sediments or suspended particles; in areas where the amount of solid phase is limited, plutonium remains in the dissolved phase. Kd values ranging from 1X10+5 to 7X10+5 L/kg have been reported for plutonium with suspended particulate in environmental waters. It has been shown that plutonium associated with colloidal materials can be mobile in groundwater systems over large distances and can bind and transport radionuclides. Plutonium compounds are ionic and would not volatilize from water surfaces. Bioconcentration factors of 1.6X10+4 and 2X10+3 in brown macroalgae and <500 and 40 in fish muscle were reported for (plutonium-239+plutonium-240). Bioconcentration factors of 1,000 for mollusks and algae, 100 in crustacea, and 10 for fish have been reported for plutonium. Individuals working at facilities using or processing plutonium or uranium may be exposed to plutonium compounds. As plutonium is dispersed throughout the environment due to past atmospheric nuclear weapons testing, the general population will have some exposure to plutonium compounds. An estimated 50-year dose from plutonium due to atmospheric nuclear weapons testing conducted before 1973 is 0.2 millirad for individuals living in the north temperate zone of the earth. Individual living near facilities that use or process plutonium may have higher exposures to plutonium compounds than the general population. (SRC)
**PEER REVIEWED**


Other Chemical/Physical Properties :
DECAY PATHWAY: Plutonium-241, half-life 14.35 years, decays via beta (-) emission (100%, 20.8 keV maximum, 5.23 keV average energy) to americium-241, half-life 432.2 years; decays via alpha emission, 5683 keV (84.5% 5486 keV; 13.0% 5443keV) to neptunium-237, half-life 2,144,000 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Radiation Limits & Potential :
DECAY PATHWAY: Plutonium-241, half-life 14.35 years, decays via beta (-) emission (100%, 20.8 keV maximum, 5.23 keV average energy) to americium-241, half-life 432.2 years; decays via alpha emission, 5683 keV (84.5% 5486 keV; 13.0% 5443keV) to neptunium-237, half-life 2,144,000 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Cleanup Methods :
A pamphlet published by the Energy Research and Development Administration in May 1976 entitled Radioactive Waste Management at Hanford describes one type of traditional reprocessing plant ... /that is/ designed for recovery of neptunium as well as plutonium and uranium. The Purex Extraction portion of the Hanford Reprocessing Plant has processing equipment for sequentially dissolving depleted fuel rods, treating such solutions with extractants for the recovery of components such as plutonium and uranium and for the isolation of fission products. ... The depleted fuel rods are dissolved to provide an aqueous solution which is subjected to solvent extraction to recover the plutonium. ... The ... plutonium stream is purified by a series of processing steps. The fission products are separated and processed in an appropriate manner.
[Duffy, J.I. (ed.). Treatment, Recovery, and Disposal Processes for Radioactive Wastes-Recent Advances. Park Ridge, New Jersey: Noyes Data Corporation, 1983., p. 177]**PEER REVIEWED**


Methods of Manufacturing :
Commercial electric-power generating reactors generally produce plutonium by irradiating uranium fuels to a total neutron exposure of more than 5000 megawatt days per ton. The recoverable plutonium contains a larger fraction of heavier isotopes. The rate of production and the isotopic composition depends on the reactor type and method of operation, which depend on economics. In boiling water reactors (BWR) and pressurized-water reactors (PWR), the rates of production are 270 and 360 g plutonium per electrical megawatt yr of operation, respectively.
[Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V19: 409 (1996)]**PEER REVIEWED**


General Manufacturing Information :
Upon fission, one gram of plutonium releases energy equivalent to that produced by combustion of three metric tons of coal. In plutonium-fueled breeder power reactors, more plutonium is produced than is consumed.
[Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V19: 409 (1996)]**PEER REVIEWED**


Human Toxicity Excerpts :
/CASE REPORTS/ /ACUTE RADIATION SYNDROME/ The accident ... occurred as a result of reactor criticality ... . A large reactivity change as made manually during testing control rods in the ZPR assembly causing a power excursion. Three workers (A, B, and C) were on a platform surrounding the reactor tank while another worker (D) leaned over the the tank and unclamped and withdrew a control rod. A dull "thud" was heard and a blue light emanated from the top of the reactor. The control rod was dropped back in and the workers left the room. The patients were seen within 10 minutes by a physician. They were asymptomatic and transported to a hospital. The doses were about 1.59, 1.26, 0.61, and 0.11 Gy. Only patient A was symptomatic. No fatalities resulted from this accident. /Fissionable plutonium/
[Gusev, I.A., Guskova, A.K., Mettler, F.A. (eds) Medical Management of Radiation Accidents. Second Edition. CRC Press. Boca Raton, FL. 2001, p. 176]**PEER REVIEWED**


Spectral Properties :
Characteristic Emission Lines: L(beta1)L2M4= 0.67772; L(lambda)L3M1= 1.0226; L(alpha1)L3M5= 0.86830; L(beta2)L3N5= 0.71851.
[Robinson JW (ed.); Handbook of Spectroscopy Vol 1 Baton Rouge, La: CRC Press Inc., 22 (1979)]**PEER REVIEWED**


Other Chemical/Physical Properties :
DECAY PATHWAY: Plutonium-238, half-life 87.7 years, decays via alpha emission, 5593 keV (70.9% 5499 keV; 28.9% 5456 keV) to uranium-234, half-life 245,500 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Other Chemical/Physical Properties :
DECAY PATHWAY: Plutonium-239, half-life 24,110 years, decays via alpha emission, 5245 keV (73.3% 5156 keV; 15.1% 5144 keV) to uranium-235, half-life 7.028X10+8 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Other Chemical/Physical Properties :
DECAY PATHWAY: Plutonium-240, half-life 6564 years, decays via alpha emission, 5256 keV (72.8% 5168 keV; 27.1% 5144 keV) to uranium-235, half-life 2.342X10+7 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Other Chemical/Physical Properties :
DECAY PATHWAY: Plutonium-242, half-life 373,300 years, decays via alpha emission, 4984 keV (77.5% 4901 keV; 22.4% 4856 keV) to uranium-238, half-life 4.468X10+9 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Radiation Limits & Potential :
DECAY PATHWAY: Plutonium-238, half-life 87.7 years, decays via alpha emission, 5593 keV (70.9% 5499 keV; 28.9% 5456 keV) to uranium-234, half-life 245,500 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Radiation Limits & Potential :
DECAY PATHWAY: Plutonium-239, half-life 24,110 years, decays via alpha emission, 5245 keV (73.3% 5156 keV; 15.1% 5144 keV) to uranium-235, half-life 7.028X10+8 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Radiation Limits & Potential :
DECAY PATHWAY: Plutonium-240, half-life 6564 years, decays via alpha emission, 5256 keV (72.8% 5168 keV; 27.1% 5144 keV) to uranium-235, half-life 2.342X10+7 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Radiation Limits & Potential :
DECAY PATHWAY: Plutonium-242, half-life 373,300 years, decays via alpha emission, 4984 keV (77.5% 4901 keV; 22.4% 4856 keV) to uranium-238, half-life 4.468X10+9 years
[Korea Atomic Energy Research Institute. Nuclear Data Evaluation Lab. 2000. Nuclide Table. Available from the database query page at http://atom.kaeri.re.kr/ton/ as of Nov 18, 2005. ]**PEER REVIEWED**


Radiation Limits & Potential :
The plutonium isotopes emit relatively few high-energy gamma rays, so even kilogram quantities can be processed without serious gamma-exposure problems. Because of the high density of plutonium, many gamma rays are self-absorbed. In some instances, the decay products may become significant in radiation protection and metallurgy. For instance, the isotope plutonium-236 often constitutes less than 1% of plutonium and is often ignored in dose calculations. However, if the plutonium is shielded by greater than 1 cm of lead or steel, the decay products of plutonium-236 may be the largest contributors to exposure. The decay product thallium-208 emits a highly penetrating gamma ray with an energy of 2.615 MeV. In plutonium that contains a few weight percent plutonium-241, the americium-241 decay product is important because it emits a large number of 60-keV photons, which can be a significant source of exposure to the hands and forearms when handling plutonium in gloveboxes. Also, americium-241 can contribute to neutron dose. Americium-241 contributes to increased alpha emission which affects the neutron dose as well as radiolysis and helium retention and release. Because of its importance to radiation exposure, the fractional amount of americium-241 produced by beta decay from plutonium-241 is given as a function of time since chemical separation.
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. P 2-8 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Antidote and Emergency Treatment :
A nuclear accident dosimetry program/at the facility/ should provide absorbed dose information/to the medical team/ within 24 hours after the incident. ... A common initial screening method is to provide all workers in areas requiring nuclear accident dosimetry with an indium foil in their personnel dosimeter or security badge. During a criticality excursion the foil will become activated by neutrons per the indium-115(n, gamma) indium-116m reaction and can be measured with a portable beta-gamma survey instrument or ion chamber. The indium-116m has a 54-min half-life and releases a 1-MeV beta (maximum energy) and a 1.3-MeV gamma (80% of the time). An alternate screening is to measure body activity due to neutron activation of the sodium in the blood via the sodium-23 (n, gamma) sodium-24 reaction. Sodium-24 has 15-hour half-life and releases a 1.4-MeV beta (maximum energy) and two gammas (1.37 MeV and 2.75 MeV). A beta-gamma survey meter is used to measure the sodium-24 activity in the blood by placing the detector probe against the individual's abdomen and having the individual bend forward to enclose the detector. Alternatively, the probe can be positioned under the armpit with the open window facing the chest area. ...Tthis method is less sensitive than the use of indium foils and even a small reading can indicate a significant exposure.
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. p 7-17,18 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Atmospheric Concentrations :
On the basis of the measured and inferred plutonium concentration in the air of New York and a constant inhalation rate of 20 cu m/day, inhalation intake reflects the amt of radioactivity released by nuclear weapons tests. In 1960 ... the amt diminished & rose again in 1963 to a max of 450 mbecquerel following 1961-1962 /nuclear weapons tests/. ... declined regularly after the Test Ban Treaty of 1963 to a value of about 7 mbecquerel/yr during the period from 1972-1974.
[Seiler, H.G., H. Sigel and A. Sigel (eds.). Handbook on the Toxicity of Inorganic Compounds. New York, NY: Marcel Dekker, Inc. 1988., p. 726]**PEER REVIEWED**


Probable Routes of Human Exposure :
Individuals working at facilities using or processing plutonium or uranium may be exposed to plutonium compounds(1). As plutonium is dispersed throughout the environment due to past atmospheric nuclear weapons testing, the general population will have some exposure to plutonium compounds(SRC). An estimated 50-year dose from plutonium due to atmospheric nuclear weapons testing conducted before 1973 is 0.2 millirad for individuals living in the north temperate zone of the earth(1). Individual living near facilities that use or process plutonium may have higher exposures to plutonium compounds than the general population(SRC).
[(1) ATSDR; Toxicological Profile for Plutonium. December 1990. Dept Hlth Human Serv., Public Hlth Service, Agency for Toxic Substances and Disease Registry pp. 87-106 (1990) ]**PEER REVIEWED**


Human Toxicity Excerpts :
/CASE REPORTS/ /WOUND CONTAMINATION/ Glovebox Accident Involving Plutonium-Americium Contamination and Hand Amputation. An employee ... in plutonium fuel fabrication reached for an item in his glovebox and his glove was caught by a milling machine that tore off his right hand. /An hour later/ ... patient /arrived at the treatment center. ... The patient was surveyed for external contamination while in the ambulance. No widespread removable contamination was found, so the patient was brought in and placed on a decontamination table /at which time the attending physician/ learned that the patient had lost his right hand at the wrist. /A half-hr later/ the plant health physics supervisor arrived with the contaminated hand wrapped in plastic in an ice bucket. The hand was immediately counted ... and the patient's stump was counted ... with a ... NaI crystal. An initial estimate ... indicated ... an amount, if entering bone, /that/ could result in bone dose commitments in the tens of millions of rem ... Additional measurements /after ....debridements/ indicated that ... remaining contamination on the hand and stump was still more than 100 times the Maximum Permissible Body Burden (MPBB). .... The difficult decision was made by the patient and his family, as well as the involved physicians and health physicists, to reattach the hand despite its excessive residual radioactivity. Considerations included the youth of the worker, his right-handedness, location of the radioactivity, the availability of DTPA chelation therapy, and the likelihood of the patient's availability of multiyear observation. ... Unfortunately, circulation in the fingers of the reattached hand did not improve quickly enough for tissue survival, so the hand was reamputated, ... infused with formaldehyde and recounted ... showing about 4 uCi (about 100 MPBB) still on the surface. ... Since reamputation of the hand was done approximately an inch higher than the original accidental amputation, the reamputated hand turned out to contain practically all of the remaining contamination. ... The medical management of an injured and contaminated patient in this case required at least about two person-days of professional dedication of a medical-health physics team already experienced with accidents involving external and internal contamination with americium-plutonium mixtures; this input was in addition to collaboration with a number of other physicians and medical and health physics technicians. The average medical institution likely to receive contaminated victims of a terrorist attack will not have such personnel or equipment resources. Any expectation of a medical capacity for triage and management of such patients requires prior training and equipping of personnel in each medical institution for the simplest counting and spectrometric measurements, and ready-made methods of data interpretation.
[Brodsky, A., et al; Chapter 20 in Public Protection from Nuclear, Chemical, and Biological Terrorism p 353-7. Medical Physics Publishing, Madison, Wisconsin (2004) ]**PEER REVIEWED**


Human Toxicity Excerpts :
/EPIDEMIOLOGY STUDIES/ The authors conducted a nested case-control study of the association between lung cancer mortality and cumulative internal lung doses among a cohort of workers employed at the Rocky Flats /Plutonium/ Plant in Colorado from 1951 to 1989. Cases (n = 180) were individually matched with controls (n = 720) on age, sex, and birth year. Annual doses to the lung from plutonium, americium, and uranium isotopes were calculated for each worker with an internal dosimetry model. Lung cancer risk was elevated among workers with cumulative internal lung doses of more than 400 mSv in several different analytical models. The dose-response relation was not consistent at high doses. Restricting analysis to those employed for 15-25 years produced a statistically significant linear trend with dose (chi-square = 67.2, p < 0.001), suggesting a strong healthy worker survivor effect. The association between age at first internal lung dose and lung cancer mortality was statistically significant (odds ratio = 1.05, 95% confidence interval: 1.01, 1.10). No associations were found between lung cancer mortality and cumulative external penetrating radiation dose or cumulative exposures to asbestos, beryllium, hexavalent chromium, or nickel. /Plutonium, NOS/
[Brown SC et al; Am J Epidemiol 160 (2): 163-72 (2004) ]**PEER REVIEWED** PubMed Abstract


Human Toxicity Excerpts :
/EPIDEMIOLOGY STUDIES/ Cases of lung cancer among Mayak workers who were exposed to plutonium were described ... . The incidence in workers who received cumulative doses of external gamma-radiation higher than those permissible at the time (most received doses > 100 roentgen (about 1 Gy) and > 0.02 uCi [740 Bq] plutonium to the lung) 20 years after the beginning of exposure was significantly higher than that in workers exposed to the same types of radiation within permissible dose limits or in those who had never worked at Mayak. Since that time, three epidemiological studies have been conducted ... a cohort study by the epidemiology department, a cohort study by the internal dosimetry laboratory, and a case-control study by the clinical department. These studies are based on partially overlapping material. ... In the study by the epidemiology department, mortality ... from lung cancer was analyzed only for workers who were hired during the first decade of operations at Mayak (1948-58) ... . The number of lung cancer deaths observed in the cohort was 105, and the expected numbers calculated from national statistics and for the internal control group were 42.18 and 40.67, respectively. The risk for lung cancer increased with the total dose of alpha-particles to the lung ... /and/ no association was detected between death from lung cancer and the whole-body dose of gamma-radiation. A significantly elevated rate of mortality from lung cancer over the national average was ... /also/ reported ... among 666 women hired at the radiochemical and plutonium production plant in 1948-58. ... The number of observed cases (15) was significantly higher than that expected (2.57), and the risk for cancer mortality was associated with the total dose of alpha-radiation to the lung. Most of the deaths occurred among workers with the highest equivalent dose of alpha particles to the lung (> 100 Sv). ... Another cohort study was conducted at the ... internal dosimetry laboratory ... /and/ 80 lung cancer deaths /were reported/, while 48.17 were expected (31.83 excess deaths). All the excess deaths were concentrated in the dose category > 4.0 Sv ... . The results of the case-control study of lung cancer in Mayak workers conducted at the ... clinical department ... /which identified/ 11 potential risk factors /with/ six significant ones. One was plutonium deposition in body. ... /Examination of the distribution of lung cancers by lobe in 131 male workers at Mayak and in 178 men who had never worked at Mayak ... /found/ ... the lung cancers in the study subjects were located in the lower lobe more frequently (45%) than in ... the control groups (25%), although the lung content of plutonium is higher in the upper lobe of the lung. Mayak workers (168 cases: 154 men, 14 women) /were compared with/ ... unexposed population controls (157 control cases: 144 men, 13 women) ... the percentage of adenocarcinomas was higher in the workers (46%) than in the unexposed population (33%), and the highest percentage of adenocarcinomas (74%) was found among workers with plutonium body burdens of > 11.0 kBq. /Plutonium, NOS/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 195-206 (2001)]**PEER REVIEWED**


Absorption, Distribution & Excretion :
This paper presents the analysis of urine bioassay data, spanning four decades, from five workers who had wounds contaminated with plutonium at the Department of Energy Rocky Flats Plant during the period 1961to 1967. The cases were selected from participants in the Department of Energy-sponsored Former Radiation Worker Medical Surveillance Program at Rocky Flats, which provided medical monitoring, modern bioassay measurements, and internal dose re-evaluations for former Rocky Flats workers. The cases include a variety of wound types, excision treatment regimes, and monitoring information. These wound cases illustrate the use of two multi-compartment wound models and three plutonium urine excretion models for retrospective calculation of internal plutonium depositions resulting from wounds for which no chelation therapy was administered. Wound model compartment fractions and half times are determined for each case and urine excretion model as are composite parameter values. The urine analysis and wound count measurements obtained under the program provide data with state-of-the art measurement sensitivity, as well as the opportunity to include long-term excretion and wound site data that exceed 10,000 d post-exposure for retrospective intake and dose evaluations. These data are provided to the radiation dosimetry community for use in developing and testing improved models for plutonium deposition in wounds.
[Falk RB et al; Hlth Phys 91 (2): 128-43 (2006) ]**PEER REVIEWED** PubMed Abstract


Environmental Fate :
TERRESTRIAL FATE: Plutonium is generally immobile in soil(1,2). This is due to the insolubility of PuO2, the predominant form of plutonium found in fallout particles, and the interaction of Pu(IV) hydrolysis products with soil, minerals, and organic, surfaces(2). PuO2 remains within the top few centimeters of soil(1). Only a small fraction (<0.1%) of plutonium in soils is soluble and may be mobile in soils and taken up by plants(2). The mobility of plutonium in soils may be due to the presence of complexing agents or valence states other than Pu(IV), that are less likely to undergo hydrolysis, forming insoluble plutonium compounds(2). Physical processes, such as cultivation of soil, may redistribute plutonium compounds between soil layers(2). Erosion by wind and water will also transport plutonium compounds found in surface soils through the environment(2). Plutonium compounds are ionic and will not volatilize from dry or moist soil surfaces(SRC).
[(1) ATSDR; Toxicological Profile for Plutonium. December 1990. Dept Hlth Human Serv., Public Hlth Service, Agency for Toxic Substances and Disease Registry pp. 87-106 (1990) (2) WHO; Environmental Health Criteria 25, Radionuclides, selected. World Health Org (1983) Available at http://www.inchem.org/documents/ehc/ehc/ehc25.htm as of Nov 9, 2005. ]**PEER REVIEWED**


Soil Adsorption/Mobility :
Plutonium is generally immobile in soil(1,2). This is due to the insolubility of PuO2, the predominant form of plutonium found in fallout particles, and the interaction of Pu(IV) hydrolysis products with soil, minerals, and organic, surfaces(2). PuO2 remains within the top few centimeters of soil(1). Only a small fraction (<0.1%) of plutonium in soils is soluble and may be mobile in soils and taken up by plants(2). The mobility of plutonium in soils may be due to the presence of complexing agents or valence states other than Pu(IV), that are less likely to undergo hydrolysis, forming insoluble plutonium compounds(2). Partition coefficients (Kd) ranging from 8X10+4 to 1.5X10+5 were determined for (239+240)Pu in arctic surface sediments from the Kara Sea(3). The behavior of plutonium in soil is pH dependent(4). In the pH range of 2 to 8.5 soluble plutonium is essentially completely sorbed, while in the range of pH 8.5-12 sorption decreased, with a minimum sorption (approx. 85%) observed at pH 12(4). Above pH 12.5, essentially complete sorption was observed(4). Distribution coefficients for soluble plutonium in Savannah River soil was found to be a function of pH and oxidation state(4). Plutonium sorption was >95% complete (Kd>100) starting at pH 2.5 for Pu(III) and Pu(IV) and at pH 7 for Pu(V)(4). At pH 6-7 sorption reached a maximum (Kd approx. 10,000) for Pu(III) and Pu(IV) and at pH 8 for Pu(VI) (Kd approx. 1,000)(4). At pH 12 the Kd values were >100 for all three oxidation states(4). In a study using 13 soils plutonium sorption was found to be high, with 62% of the measurements showing sorption of 99% or higher and the lowest sorption measured was 87%(4). A Kd of 1.4X10+5 L/kg was estimated for plutonium for suspended solids in the surface Mediterranean coastal waters(5). Kd values ranging from 1X10+5 to 7X10+5 L/kg were reported for plutonium for suspended particulate in the Savannah River Estuary, GA(6).
[(1) ATSDR; Toxicological Profile for Plutonium. December 1990. Dept Hlth Human Serv., Public Hlth Service, Agency for Toxic Substances and Disease Registry pp. 87-106 (1990) (2) WHO; Environmental Health Criteria 25, Radionuclides, selected. World Health Org (1983). Available at http://www.inchem.org/documents/ehc/ehc/ehc25.htm as of Nov 9, 2005. (3) Fisher NS et al; Environ Sci Technol 33: 1979-82(1999) (4) Miner FJ et al; Plutonium Behavior in the Soil/water Environment. Part 1. Sorption of Plutonium by Soils. Part II. Selected Chemical and Physical Characteristics of Aqueous Plutonium and Their Effects on the Sorption of Plutonium by Soils. RFP-2480. (NTIS DE83006587). Golden, Co: Rockwell Inter. Div. 23. pp. 80. (1982) (5) Molero J et al; J Environ Radiat 28: 271-83 (1995) (6) Olsen CR et al; Environ Sci Technol 23: 1475-81 (1989) ]**PEER REVIEWED**


Body Burden :
Plutonium-239 and plutonium-240 cannot be distinguished by alpha spectroscopy and are usually reported together(1). Plutonium-239 concentrations in tissues from 12 autopsy cases in New York City (1973-76) were 0.00024, 0.0007, 0.00017, and 0.0004 pCi/g in lung, liver, vertebrae, and gonads, respectively(2). Median plutonium-239+plutonium-240 concentrations of 0.00016, 0.00012, 0.000095, 0.0007 and 0.000049 pCi/g in ribs, vertebrae, femur, liver and lungs, respectively, were reported in tissues samples from autopsy cases of non-occupationally exposed individuals from Great Britain(2). Plutonium-239+plutonium-240 concentrations of 0.00022, 0.00019, 0.00015, 0.00014, and 0.00018 pCi/g in ribs, vertebrae, femur, liver and lungs, respectively, were reported in tissues samples from autopsy cases of individuals living near a plutonium processing plant in Great Britain(2).
[(1) Eisenbud M, Gesell T, eds; Environmental radioactivity. 4th ed. San Diego, CA: Academic Press. pp. 310-311 (1997) (2) ATSDR; Toxicological Profile for Plutonium. December 1990. Dept Hlth Human Serv., Public Hlth Service, Agency for Toxic Substances and Disease Registry pp. 87-106 (1990) ]**PEER REVIEWED**


Analytic Laboratory Methods :
SOLVENT EXTRACTION. A wide variety of organic extractants have been developed to separate plutonium from other radionuclides and metals by selectively extracting them from aqueous media. The extractants, among others, include organophosphorus compounds such as phosphates (organoesters of phosphoric acid), amines and their quaternary salts, alcohols, ketones, ethers, and amides. Chelating agents such as thenoyltrifluoroacetone (TTA) and cupferron have also been used. Numerous studies have been performed on the behavior of these systems. It has been found that the performance of an extracting system is primarily related to the organic solvent in which the extractant is dissolved and the concentration of the extractant in the solvent, the nature of the aqueous medium (the acid present and its concentration [pH] and the presence of salting agents), the temperature of the system, and the presence and nature of oxidizing agents. One common system, used extensively in the laboratory and in industrial process to extract plutonium from fission products, illustrates the use of solvent extraction to separate plutonium from uranium and other metals. The PUREX process (plutonium uranium reduction extraction) is used in most fuel reprocessing plants to separate the radionuclides. It employs TBP, tri-n-butyl phosphate ((C4H9O)3PO), in a hydrocarbon solvent, as the extractant. The uranium fuel is dissolved in nitric acid as Pu+3, and plutonium is oxidized to Pu+4 and uranium to U(VI) by oxidizing agents. Plutonium and uranium are extracted into a 30 percent TBP solution, and the organic phase is scrubbed with nitric acid solution to remove impurities. The plutonium is removed by backextracting it as Pu+3 with a nitric acid solution containing a reducing agent. Solvent extraction chromatography, which uses an inert polymeric material as the
[Multi-Agency Radiological Laboratory Analytical Protocols Manual Volume II: Chapters 10-17 and Appendix F. (July 2004) p 14-146 NUREG-1576, EPA 402-B-04-001B, NTIS PB2004-105421. Available at http://www.nrc.gov/reading-rm/doc-collections/nuregs/staff/sr1576/sr1576v2.pdf as of October 12, 2006 ]**PEER REVIEWED**


Clinical Laboratory Methods :
Method: spectrometry; Sample Preparation: dissolve starch; filter; wet ash; extract, electrodeposit on platinum disk; Analyte: plutonium; Matrix: plant; Detection Limit: 0.0027 pCi (0.1x10-4 Bq). /From table; Plutonium-238. Plutonium-239; Plutonium-240/
[DHHS/ATSDR; Toxicological Profile for Plutonium p.108 (December 1990). Available from: http://www.atsdr.cdc.gov/toxprofiles/tp143.html as of November 23, 2005 ]**PEER REVIEWED**


Prior History of Accidents :
Mayak Production Association, 10 December 1968. An unfavorable geometry vessel was being used in an improvised and unapproved operation as a temporary vessel for storing plutonium organic solution. Two independent handling operations with the same vessel and same contents less than one hour apart led to two prompt critical excursions, each one resulting in the severe exposure of a worker... . /Both were sent to the decontamination and medical facility at the plant in Mayak and then/ were flown to Moscow for treatment. Samples of their blood showed very high sodium-24 activities. Adjusted to the instant of the exposure, they were 5,000 decays/min/mL (83 Bq/cm3) for the operator and 15,800 decays/min/mL (263 Bq/cm3) for the shift supervisor. The operator received an estimated absorbed dose of about 700 rem and the shift supervisor about 2,450 rem. The operator developed acute, severe radiation sickness; both his legs and one hand were amputated. He was still living 31 years after the accident. The shift supervisor died about one month after the accident.
[McLaughlin TP et al; A Review of Criticality Accidents - 2000 revision. Los Alamos National Laboratory, LA-13638. Available at http://www.eh.doe.gov/paa/nsr/nsrsearch/catalog/758324.pdf as of October 4, 2006 ]**PEER REVIEWED**


Methods of Manufacturing :
Plutonium-239 is produced in a nuclear reactor by neutron bombardment of the nonfissionable isotope uranium-238. /Plutonium-239/
[Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 14th Edition. John Wiley & Sons, Inc. New York, NY 2001., p. 888]**PEER REVIEWED**


Methods of Manufacturing :
Bulk quantities of plutonium are produced through neutron capture by uranium-238 in nuclear reactors. /Plutonium-239/
[Gerhartz, W. (exec ed.). Ullmann's Encyclopedia of Industrial Chemistry. 5th ed.Vol A1: Deerfield Beach, FL: VCH Publishers, 1985 to Present., p. VA21: 133 (1992)]**PEER REVIEWED**


Formulations/Preparations :
Plutonium-238: Produced from transmutation of neptunium-237 by neutron capture. Available in milligram quantities as oxide powder at radiopurity of 80-97%. Plutonium-239: Produced by neutron irradiation of uranium-238 and electromagnetic separation. Available in milligram units as oxide powder at radiopurity of 99-99.99%. Plutonium-240: Produced by transmutation of neptunium or processing of curium-244. Available in milligram quantities as oxide powder at a radiopurity of 75-95%. Plutonium-241: Prepared by sequential neutron captures in uranium-238/plutonium by electromagnetic separation of plutonium. Available in milligram quantities as oxide powder at a radiopurity of 80-93%. All are classed as nuclear naterial requiring documentation of transfer. /Plutonium isotopes/
[DOE; Isotope Catalog Product Menu: Plutonium. Available at http://www.ornl.gov/sci/isotopes/catalog.htm as of October 2, 2006 ]**PEER REVIEWED**


Major Uses :
Weapons grade plutonium has the highest content of plutonium-239 and is mainly used in nuclear warheads.
[U.S. Department of Energy; DOE Standard. Radiological Safety Training for Plutonium Facilities. Instructors Manual. p 4 DOE-HDBK-1145-2001 (2001) ]**PEER REVIEWED**


Fire Fighting Procedures :
Fire extinguishing must contain the plutonium and should not create a nuclear criticality potential. The preferred method of extinguishing a plutonium fire is by excluding oxygen, either by inerting the glove-box atmosphere or by smothering the plutonium with a powder, eg, graphite, magnesia, or sodium carbonate. Controlled burning of plutonium also is recommended. /Fissile plutonium/
[Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 18(82) 298]**PEER REVIEWED**


Cleanup Methods :
Decontamination is most successful when the material can be recycled for use in a nuclear facility since the need to prove releasability (cleanliness) is eliminated. Nevertheless, cleaning material for unrestricted release is also possible in some cases. It may also be possible to decontaminate an item enough to change its classification from TRU/transuranic/ waste to LLW /low-level waste/, thereby allowing immediate disposal of the item, while a relatively small quantity of decontamination waste is stored as TRU waste. Electropolishing to remove the thinnest metal surface has been very effective and produces a relatively small waste volume, especially when one of the wetted sponge units is used rather than an emersion tank. Surface scabbling has been used in decontamination of concrete, and various abrasive blasting methods have also been effective. Strippable and self-stripping coatings may be used to decontaminate surfaces, even though the primary application of strippable coatings has been in preventing contamination of surfaces. /Plutonium compounds/
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. p 8-16, 17 DOE-STD-1128-98 (1998)8-16 8-1 ]**PEER REVIEWED**


Antidote and Emergency Treatment :
As an immediate follow-up action for workers identified as being exposed during a quicksort procedure, /the health physicist evaluating the incident should make/ a more accurate dose estimate ... using personal nuclear accident dosimeters, fixed location accident dosimeters, or biological activity analyses (sodium-24 in the blood or phosphorous-32 in the hair). Part of these more accurate analyses should include: 1) better definition of source characteristics, 2) location of moderating materials, and 3) location and orientation of the person(s) at the time of exposure and action of the person following the irradiation. The health physics staff can provide valuable information to support this analysis, particularly regarding the location and orientation of workers to the excursion if they are involved in the rescue and initial monitoring procedures.
[U.S. Department of Energy; Guide of Good Practices for Occupational Radiological Protection in Plutonium Facilities. p 7-23 DOE-STD-1128-98 (1998) ]**PEER REVIEWED**


Human Toxicity Excerpts :
/EPIDEMIOLOGY STUDIES/ Deaths among 5,413 workers employed at the Rocky Flats, Colorado, nuclear weapons facility were investigated in order to estimate the risks from exposure to plutonium and external radiation. The cohort consisted of all white men who had been employed at this facility for at least two years between the beginning of operations in 1952 and 1979. In comparison with death rates for the USA, significantly fewer deaths from all causes, all cancers, lung cancer, circulatory system diseases and accidents, poisonings and violence were observed. .... No bone tumors occurred in this cohort. A significant excess of benign and unspecified neoplasms was found; all seven cases were intracranial tumors. In a case-control study of the brain tumors at Rocky Flats, no statistically significant association was found with exposure to either external radiation or plutonium ... . /Plutonium, NOS/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 193-4 (2001)]**PEER REVIEWED**


Human Toxicity Excerpts :
/EPIDEMIOLOGY STUDIES/ Prompted by a case of lung fibrosis in a retired plutonium worker, /the authors/ tested the hypothesis that plutonium inhalation increases the risk for developing chest radiograph abnormalities consistent with pulmonary fibrosis. /The authors/ conducted a retrospective study of nuclear weapons workers that included estimating absorbed doses to the lung with an internal dosimetry model. /The/ study population consisted of 326 plutonium-exposed workers with absorbed lung doses from 0 to 28 Sv and 194 unexposed workers. ...The severity of chest radiograph interstitial abnormalities /were compared/ between the two groups using the International Labour Organization profusion scoring system. There was a significantly higher proportion of abnormal profusion scores among plutonium-exposed workers (17.5%) than among unexposed workers (7.2%), P < 0.01. Lung doses of 10 Sv or greater conferred a 5.3-fold risk (95% CI 1.2-23.4) of having an abnormal chest X ray consistent with pulmonary fibrosis when compared with unexposed individuals after controlling for the effects of age, smoking and asbestos exposure. This study shows that plutonium may cause lung fibrosis in humans at absorbed lung doses above 10 Sv. /Plutonium, NOS/
[Newman LS et al; Radiat Res 164 (2): 123-31(2005) ]**PEER REVIEWED** PubMed Abstract


Human Toxicity Excerpts :
/BIOMONITORING/ Chromosomal aberrations in human peripheral blood lymphocytes are a recognized indicator of exposure to ionizing radiation in vivo. An increase in the frequency of chromosomal aberrations above the background level reflects direct exposure of circulating lymphocytes and also exposure of hematopoietic precursor cells in the bone marrow ... . A banding technique that allows recognition of many symmetrical aberrations which would be missed with conventional staining was used to analyze peripheral blood lymphocytes from 54 plutonium workers from the British Nuclear Fuels facility at Sellafield, United Kingdom. These workers had body burdens in excess of 296 Bq ... all had been exposed at least 10 years before the analysis. These workers had also been exposed to significant levels of external gamma-radiation. The controls were 39 newly hired workers with no known exposure to radiation or known clastogenic chemical ... /The/ ... plutonium workers showed increased frequencies of both symmetrical and asymmetrical chromosomal aberrations over those in controls. ... Twenty-four of the workers in the above study were still employed at Sellafield and therefore available for resampling 10 years later. Analysis of chromosomes in G-banded peripheral blood lymphocytes was performed on two groups of workers who had 20-50% and >50% of the maximum permissible body burden of plutonium. A significant increase was found in the frequencies of symmetrical aberrations in both groups when compared with workers with similar histories of exposure to mainly external gamma-radiation but with little or no intake of plutonium and with controls with negligible exposure, estimated to be < 50 mSv. /Plutonium, NOS/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 445 (2001)]**PEER REVIEWED**


Human Toxicity Excerpts :
/BIOMONITORING/ /GENOTOXICITY/ /The authors/ recently demonstrated that a significant proportion of apparently stable insertions induced after exposure to a mean of one alpha particle/cell, detected using three-color FISH, were part of larger unstable complexes when visualized by 24-color FISH. Interestingly, regardless of the long-term persistence capability of the cell, the complexity of each alpha-particle-induced complex appeared to be specific to the nuclear traversal of a single alpha particle. To assess whether aberrations of a similar complexity are observed in vivo and also to examine the usefulness of detecting such aberrations as a biomarker of chronic exposure to alpha particles, /they/ have carried out a limited pilot study of Russian workers with large body burdens of alpha-particle-emitting plutonium. ... Uunstable cells containing non-transmissible complex aberrations /were found/ in all of the plutonium-exposed subjects analyzed by mFISH. In addition, all of the complexes seen were consistent with those previously observed in vitro. Non-transmissible complex aberrations were more common than transmissible-type complexes, consistent with ongoing/chronic exposure, and insertions were dominant features of both types of complex. Accordingly, this preliminary study supports the proposal that aberration complexity and non-transmissibility are the major cytogenetic features of alpha-particle exposure that could potentially be exploited as a specific indicator of chronic exposures to high-LET alpha particles. /Plutonium, NOS/
[Anderson RM et al; Radiat Res 163 (1): 26-35 (2005) ]**PEER REVIEWED** PubMed Abstract


Ecotoxicity Excerpts :
/FIELD STUDIES/Since 1946, personnel from the School of Fisheries, University of Washington (Applied Fisheries Laboratory, 1943-1958; Laboratory of Radiation Biology, 1958-1967; and Laboratory of Radiation Ecology, since 1967), have studied the effects of nuclear detonations and the ensuing radioactivity on the marine and terrestrial environments throughout the Central Pacific. A collection of reports and publications about these activities plus a collection of several thousand samples from these periods are kept at the School of Fisheries. General findings from the surveys show that (1) fission products were prevalent in organisms of the terrestrial environment whereas activation products were prevalent in marine organisms; (2) the best biological indicators of fallout radionuclides by environments were (a) terrestrial-coconuts, land crabs; (b) reef-algae, invertebrates; and (c) marine-plankton, fish. Studies of plutonium and americium in Bikini Atoll showed that during 1971-1977 the highest concentrations of americium-241, 2.85 Bq/g (77 pCi/g) and plutonium-239,-240, 4.44 Bq/g (120 pCi/g), in surface sediments were found in the northwest part of the lagoon. The concentrations in the bomb craters were substantially lower than these values. Concentrations of soluble and particulate plutonium and americium in surface and deep water samples showed distributions similar to the sediment samples. That is, the highest concentration of these radionuclides in the water column were at locations with highest sediment concentration. Continuous circulation of water in the lagoon and exchange of water with open ocean resulted in removal of 111G Bq/y (3 Ci/y) americium-241 and 222 G Bq/y (6 Ci/y) plutonium-239,240 into the North Equatorial Current. A summary of the surveys, findings, and the historical role of the Laboratory in radioecological studies of the Marshall Islands are presented. /Plutonium-239, -240/
[Donaldson LR et al; Health Phys 73 (1): 214-22 (1997) ]**PEER REVIEWED** PubMed Abstract


Absorption, Distribution & Excretion :
Inhalation: Measurements in human autopsy material of plutonium-239 resulting from the atmospheric testing of nuclear weapons show that a relatively high proportion of plutonium-239 is retained in lung tissue and tracheobronchial lymph nodes, consistent with low solubility. /Plutonium-239/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 355 (2001)]**PEER REVIEWED**


Absorption, Distribution & Excretion :
... Plutonium deposition in a small number of former nuclear industry workers was greatest, exclusive of the respiratory tract, in the skeleton followed by the liver, striated muscle, and other organs and tissues. These authors suggested that muscle and other soft tissue may act as a long-term storage depot for plutonium.
[McInroy J et al; Radiat Protect Dosimet 26: 151-158 (1989) as cited in U.S. Dept Health & Human Services/ATSDR; Toxicological Profile for Plutonium p.51 (1990) PB91-180406]**PEER REVIEWED**


Mechanism of Action :
Bystander effects from ionizing radiation have been detailed for a number of cell systems and a number of end points. /The authors used/ a cell culture/ex vivo rat model of respiratory tissue to determine whether a bystander effect detected in culture could also be shown in a tissue. Examination by immunofluorescence techniques of tracheal cell cultures after exposure to very low doses of alpha particles /from plutonium-238/ revealed a large proportion of cells with proliferating cell nuclear antigen (PCNA) bound in their nuclei. PCNA was selected as an end point because it is involved in both DNA repair and the changes in cell cycle that are typical of many reported bystander effects. Maximum response can be detected in up to 28% of the cells in sub-confluent cultures with a dose of only 2 mGy. At this dose less than 2% of the cell nuclei have experienced a particle traversal and less than 6% of the cells have experienced an alpha-particle traversal through either their nucleus or some part of their cytoplasm. The hypothesis that this bystander response in nontargeted cells is mediated through secreted factor(s) is presented, and supporting evidence was found using partial irradiation and co-culture experiments. Examination of the effect with excised pieces of trachea demonstrated a response similar to that seen in culture. /Plutonium-238/
[Hill MA et al; Radiat Res 163 (1): 36-44 (2005) ]**PEER REVIEWED** PubMed Abstract


Sediment/Soil Concentrations :
SOIL: Plutonium-238 concentrations in soil at an industrial area where nuclear-powered submarines are repaired and in an adjacent area were 0.5 and 1.4-2.0 Bq/kg dry weight, respectively(1).
[(1) Dovgusha VV et al; Chemosphere 42: 69-72 (2001) ]**PEER REVIEWED**


Threshold Limit Values :
The Physical Agents TLV Committee accepts the occupational exposure guidance of the International Commission on Radiological Protection (ICRP). Ionizing radiation includes particulate radiation (e.g., alpha particles and beta particles emitted from radioactive materials, and neutrons from nuclear reactors and accelerators) and electromagnetic radiation (e.g., gamma rays emitted from radioactive materials and X-rays from electron accelerators and X-ray machines) with energy greater than 12.4 electron-volts (eV) ... The guiding principle of radiation protection is to avoid all unnecessary exposures. ICRP has established principles of radiological protection. There are (1) the justification of a work practice: No work practice involving exposure to ionizing radiation should be adopted unless it produces sufficient benefit to the exposed individuals or the society to offset the detriment it causes. (2) The optimization of a workpractice: All radiation exposures must be kept as low as reasonably achievable (ALARA), economic and social factors being taken into account. (3) The individual dose limits: The radiation dose from all relevant sources should not exceed the /ICRP/ prescribed dose limits.
[American Conference of Governmental Industrial Hygienists. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. Cincinnati, OH 2006, p. 140]**PEER REVIEWED**


Analytic Laboratory Methods :
Personnel monitoring 1. External dosimetry: The most common device used to monitor worker dose is the thermoluninescent dosimeter (TLD). Dosimeters can be configured to monitor beta, gamma, X-ray, and neutron radiation. Supplemental dosimeters (TLDs in finger rings or wrist bands) may also be worn for monitoring extremity dose. There are dosimeters and gamma pencils equipped with alarms that can be used, but they must be specially made for low-energy gamma rays. Nuclear accident dosimeters (NADs) are required for facilities with sufficient quantities of plutonium to form a critical mass. They are issued to personnel and are also stationed throughout the facility. They contain different types of materials that become radioactive through neutron activation. The neutron dose is determined by evaluating the amount of activation of the NAD material.
[U.S. Department of Energy; DOE Standard. Radiological Safety Training for Plutonium Facilities. Instructors Manual. p 26 DOE-HDBK-1145-2001 (2001) ]**PEER REVIEWED**


Special Reports :
U.S. Nuclear Regulatory Commission; Regulatory Guide 8.34 - Monitoring Criteria and Methods to Calculate Occupational Radiation Doses. 1992/ Available at http://www.nrc.gov/reading-rm/doc-collections/reg-guides/occupational-health/active/8-34/index.html as of September 25, 2006

MORE ABOUT HEALTH EFFECTS

PLUTONIUM, RADIOACTIVE
CASRN: NO CAS RN


Evidence for Carcinogenicity:
There is sufficient evidence in humans that inhalation of plutonium-239 aerosols causes lung cancer, liver cancer and bone sarcoma. Exposure to plutonium-239 also entails exposure to plutonium-240 and other isotopes. /Plutonium-239/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 478 (2001)]**PEER REVIEWED**

There is sufficient evidence in experimental animals for the carcinogenicity of mixed alpha-particle emitters (radium-224, radium-226, thorium-227, thorium-228, thorium-230, thorium-232, neptunium-237, plutonium-238, plutonium-239 (together with plutonium-240), americium-241, curium-244, californium-249 and californium-252). /Mixed-alpha particle emitters/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 478 (2001)]**PEER REVIEWED**

Plutonium-239 (239-Pu) is carcinogenic to humans (Group 1). In making this overall evaluation, the Working Group noted that human exposure to 239-Pu may also include exposure to 240-Pu.
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 478 (2001)]**PEER REVIEWED**


Human Toxicity Excerpts:
/CASE REPORTS/ /ACUTE RADIATION SYNDROME/ ... An operator was adding tungsten carbide bricks to a plutonium assembly when the neutron flux began to increase rapidly. He accidentally dropped a brick onto the center of the assembly and a flash occurred that was easily visible to a guard 12 ft away. For such a glow to be visible, the radiation intensity must have been on the order of 7 million R/s. The operator then removed the last brick with his right hand and partially dismantled the assembly. He was seen at the hospital 30 min after the accident and complained of numbness and tingling of his swollen hands. The operator received an estimated dose of 2 Gy (neutrons) and 1.1 Gy (gamma). He died 24 days postexposure from the acute radiation syndrome (hematological). The guard received 0.08 Gy (neutrons) and 0.001 Gy (gamma). He died at age 62 (32 years post exposure) from acute myeloblastic leukemia. His brother also died of leukemia (and three other siblings are believed to have had cancer), so a familial component may have contributed to the disease. /Fissionable plutonium/
[Gusev, I.A., Guskova, A.K., Mettler, F.A. (eds) Medical Management of Radiation Accidents. Second Edition. CRC Press. Boca Raton, FL. 2001, p. 174]**PEER REVIEWED**

/CASE REPORTS/ /LUNG/ Twenty-five male subjects who worked with plutonium during World War II under extraordinarily crude working conditions have been followed medically for a period of 27 years. Within the past yr, 21 of these men have been examined at the Los Alamos Scientific Lab, and 3 more will be studied in 1973. /Physical exams were extensive, including routine hematological, chemical, urinary exams/. The bronchial cells of several of the subjects showed moderate to marked metaplastic change. Diseases and physical changes characteristic of a male population entering its sixth decade were observed. ... The bulk of these exposures were by inhalation, although ingestion may have occurred also. Roentgenograms were taken of the chest, pelvis, knee, and teeth. The chromosomes of lymphocytes from the peripheral blood and cells exfoliated from the pulmonary tract ... /were/ studied. Urine specimens assayed for plutonium gave a calculated current body burden (excluding the lung) ranging from 0.005 to 0.42 uCi, and low energy radiation emitted by internally deposited transuranic elements in the chest disclosed lung burdens probably of less than approx 0.01 uCi. To date, none of the medical findings in the group can be attributed definitely to internally deposited plutonium. ... It seems likely that the bulk of these exposures were by inhalation, although ingestion may have occurred also. /Plutonium, NOS/
[Stannard JN; Radioactivity and Health, A History p.1465 (1988) ]**PEER REVIEWED**

/CASE REPORTS/ /ACUTE RADIATION SYNDROME/ The accident occurred ... in a building where processing was being carried out to recover plutonium from irradiated uranium rods. Transfer of plutonium solution was made between two vessels assuming that one was empty (which was not the case). The vessel became hot, there was a gas release and the solution foamed. The yield was estimated to be about 2X10+17 fissions. This was not recognized as a criticality accident by the two workers and they continued to carry precipitate and put it back into the filter vessel. Within seconds, /one/ became ill. Within 17 hr after the accident, the specific activity of sodium-24 in the operator's blood was 245 Bq/cu m. This correlated to an estimated dose of about 30 Gy. The operator died 12 days after the accident. There were five other workers in the room, and they received doses upward of 3 Gy and all suffered from radiation sickness but recovered. /Fissionable plutonium/
[Gusev, I.A., Guskova, A.K., Mettler, F.A. (eds) Medical Management of Radiation Accidents. Second Edition. CRC Press. Boca Raton, FL. 2001, p. 176]**PEER REVIEWED**

/CASE REPORTS/ /ACUTE RADIATION SYNDROME/ The accident ... occurred as a result of reactor criticality ... . A large reactivity change as made manually during testing control rods in the ZPR assembly causing a power excursion. Three workers (A, B, and C) were on a platform surrounding the reactor tank while another worker (D) leaned over the the tank and unclamped and withdrew a control rod. A dull "thud" was heard and a blue light emanated from the top of the reactor. The control rod was dropped back in and the workers left the room. The patients were seen within 10 minutes by a physician. They were asymptomatic and transported to a hospital. The doses were about 1.59, 1.26, 0.61, and 0.11 Gy. Only patient A was symptomatic. No fatalities resulted from this accident. /Fissionable plutonium/
[Gusev, I.A., Guskova, A.K., Mettler, F.A. (eds) Medical Management of Radiation Accidents. Second Edition. CRC Press. Boca Raton, FL. 2001, p. 176]**PEER REVIEWED**

/CASE REPORTS/ /ACUTE RADIATION SYNDROME/ The accident resulted from unfavorable geometry in a vessel containing plutonium-bearing organic liquids. There were two critical excursions about 1 hour apart. A 20-L bottle was emptied into a 60-L vessel when the operator saw a flash of light and felt a pulse of heat. He immediately left the area and informed his supervisor. The excursion was estimated to have resulted in about 3x10+16 fissions. An hour later, a shift supervisor entered the area against instructions and attempted to manipulate the vessel when another excursion occurred. The second excursion yield was estimated at 1x10+17 fissions. Both men were flown to Moscow for medical treatment. Blood samples (adjusted to the time of exposure) showed 5,000 decays/min/mL (83 Bq/cu m) for the operator and 15,800 decays/min/mL (263 Bq/Cu m) for the shift supervisor. The total absorbed neutron and gamma doses were estimated to be 7 Sv for the operator and 24.5 for the shift supervisor. The shift supervisor had acute severe radiation sickness and he died about a month after the accident. The operator also had acute severe radiation sickness and survived but had to have amputations of both legs and one hand. He was still alive 31 years later. /Fissionable plutonium/
[Gusev, I.A., Guskova, A.K., Mettler, F.A. (eds) Medical Management of Radiation Accidents. Second Edition. CRC Press. Boca Raton, FL. 2001, p. 189]**PEER REVIEWED**

/CASE REPORTS/ /ACUTE RADIATION SYNDROME/ The accident occurred in a facility dealing with plutonium metal ingots. In violation of procedures, multiple metal ingots of about 11 kg (in excess of the administrative limit of 4 kg or less) were put into a glove box. Operator A saw a flash of light and noted an instantaneous rise in the temperature near his hands. As a result of thermal expansion, one ingot was expelled and the operator removed two more. The yield of the excursion was estimated to be 3x10+15 fissions. The operator received an estimated whole-body dose of 2.5 Gy and more than 20 Gy to the hands and forearms. Ultimately, amputation up to the elbows was necessary. Later he developed cataracts. Seven other workers received doses from 0.05 to 0.50 Gy. /Fissionable plutonium/
[Gusev, I.A., Guskova, A.K., Mettler, F.A. (eds) Medical Management of Radiation Accidents. Second Edition. CRC Press. Boca Raton, FL. 2001, p. 190]**PEER REVIEWED**

/CASE REPORTS/ /EYE/ The case of a worker who had been potentially exposed to external beta- and gamma-radiation and had possibly ingested or inhaled plutonium and other radionuclides /was described/. In three known incidents, his face had been contaminated with plutonium, some of which must have reached the bloodstream. After 24 years of work, the man had developed impaired vision due to cataracts. The estimated radiation dose to the eye, measured by external dosimeters, was approximately 0.8 Sv, which is below the threshold for this effect derived for gamma-radiation in the atomic bomb survivors ... /Plutonium, NOS/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 394 (2001)]**PEER REVIEWED**

/CASE REPORTS/ /ACUTE RADIATION SYNDROME/ In /this/ ... accident, criticality occurred in a plutonium sphere when two beryllium hemispheres accidentally surrounded the plutonium mass. The operator was attempting to teach another individual how to do experiments even though there were six other people in the area. Even in a sunlit room, a blue glow was easily visible as criticality occurred. The yield was about 3x10+15 fissions. The eight people in the room received 15 to 21, 3.6, 2.5, 1.6, 1.1, 0.65, 0.47, and 0.37 Sv, respectively. The operator received an estimated 15 to 21 Gy and died 9 days postexposure from the gastrointestinal type of the acute radiation syndrome. Of the seven initial survivors, one refused to participate in long-term follow-up but was alive as of 1978. Of the others, one patient who received 1.66 Gy (neutrons) and 0.26 Gy (gamma) experienced moderate to severe fatigue for 6 months, epilation, and aspermia. He died 20 years later of a myocardial infarction. Another who received 0.51 Gy (neutrons) and 0.11 Gy (gamma) had no acute radiation response but died 29 years later with clinical aplastic anemia and bacterial endocarditis. Another individual who had received 12 rad (neutrons) and 4 rad (gamma) died 18 years later of acute myelocytic leukemia. /Fissionable plutonium/
[Gusev, I.A., Guskova, A.K., Mettler, F.A. (eds) Medical Management of Radiation Accidents. Second Edition. CRC Press. Boca Raton, FL. 2001, p. 175]**PEER REVIEWED**

/CASE REPORTS/ /ACUTE RADIATION SYNDROME/ The accident involved an experimental reactor and there was an excursion during inadvertent closure of a lithium deuteride reflector around a plutonium core. There was a flash of light and two experimenters left the area. The yield was estimated to be about 5x10+15 fissions. There were two individuals involved: a facility chief, age 26, and an operator, age 36. The facility chief was close to the reactor and received an estimated gamma and neutron dose of about 3 to 3.7 Gy. The operator was also in close proximity to the reactor and received an estimated gamma and neutron dose of 5.5 Gy. During the maximal period of bone marrow depression, the patient had petechiae, bleeding from the gums, and fevers. ... The facility chief was fully recovered 3 months after exposure and returned to nonradiation work. For the operator there was essentially full bone marrow recovery at the end of the fourth month postexposure and the patient was able to return to work. Both were alive for more than 25 years. /Fissionable plutonium/
[Gusev, I.A., Guskova, A.K., Mettler, F.A. (eds) Medical Management of Radiation Accidents. Second Edition. CRC Press. Boca Raton, FL. 2001, p. 187]**PEER REVIEWED**

/CASE REPORTS/ /WHOLE BODY IRRADIATION/ Another accidental exposure ... involved a glovebox explosion that released ... plutonium-239 and americium-241 /nitrates/. ... The external contamination was spectacular. Alpha count rates on the patient ... were up to 10+6 counts per minute, ... as high as we could read. Removable contamination was all over the body, with maxima of 10,000 alpha cpm on the face and 20,000 on the legs ... , after /initial decontamination/ ... .The contamination was finally reduced very sharply with the use of Schubert's solution /3.0 g/L tartaric acid, 4.2 g/L citric acid, 8.0 g/L disodium DTPA or EDTA, 2.2 g/L calcium chloride adjusted to pH 7 with NaOH/ ...This patient had the additional complication of wounds that ... served as a residual depot of the radioactive material. ... The scar tissue was subsequently excised because there was continued high activity in the area /and/ a very diffuse distribution of the material. Our initial in vivo measurements made 1 day after the incident ... /showed a / burden ... projected to produce ... an initial bone dose of about 1,500 rem per year. Thus, DTPA treatment was ... medically indicated, if effective. The next measurements presented are at 60 days and over the time period from 70 to 130 days, during which the body content fell gradually. Repeated DTPA treatments were given during this time /but/ the lung component of this body burden could still be measured by localized external counting for up to 1 yr after the accident. Thus, the rapid translocation from the lung expected from nitrate compounds of plutonium and americium did not materialize. ... Initial estimates of plutonium uptake into blood were obtained under the assumption ... that DTPA increased plutonium excretion by about a factor of 50 on the day following treatment. The increase in urinary excretion of americium was a much lower factor (about 5 to 7); americium was later found to be more transportable from lung to systemic circulation and into urine than oxides of plutonium, even without treatment. Management lessons learned from this case ... are pertinent to the preparation of medical facilities expecting to evaluate and care for persons severely contaminated by a terrorist attack. There were long time periods between some of the urinary measurements, due to overloading of commercial laboratories that were not accustomed to analyzing many samples containing high amounts of plutonium and americium. This delayed decisions about DTPA effectiveness to some degree. In addition, the patient developed a paranoid outlook and ... underwent an episode that required psychiatric treatment. A suspected contributor to this complication was the fact that a number of different physicians ... might have presented different versions of his prognosis and consequent treatment.
[Brodsky, A., et al; Chapter 20 in Public Protection from Nuclear, Chemical, and Biological Terrorism p 3438-8. Medical Physics Publishing, Madison, Wisconsin (2004) ]**PEER REVIEWED**

/CASE REPORTS/ /WOUND CONTAMINATION/ Glovebox Accident Involving Plutonium-Americium Contamination and Hand Amputation. An employee ... in plutonium fuel fabrication reached for an item in his glovebox and his glove was caught by a milling machine that tore off his right hand. /An hour later/ ... patient /arrived at the treatment center. ... The patient was surveyed for external contamination while in the ambulance. No widespread removable contamination was found, so the patient was brought in and placed on a decontamination table /at which time the attending physician/ learned that the patient had lost his right hand at the wrist. /A half-hr later/ the plant health physics supervisor arrived with the contaminated hand wrapped in plastic in an ice bucket. The hand was immediately counted ... and the patient's stump was counted ... with a ... NaI crystal. An initial estimate ... indicated ... an amount, if entering bone, /that/ could result in bone dose commitments in the tens of millions of rem ... Additional measurements /after ....debridements/ indicated that ... remaining contamination on the hand and stump was still more than 100 times the Maximum Permissible Body Burden (MPBB). .... The difficult decision was made by the patient and his family, as well as the involved physicians and health physicists, to reattach the hand despite its excessive residual radioactivity. Considerations included the youth of the worker, his right-handedness, location of the radioactivity, the availability of DTPA chelation therapy, and the likelihood of the patient's availability of multiyear observation. ... Unfortunately, circulation in the fingers of the reattached hand did not improve quickly enough for tissue survival, so the hand was reamputated, ... infused with formaldehyde and recounted ... showing about 4 uCi (about 100 MPBB) still on the surface. ... Since reamputation of the hand was done approximately an inch higher than the original accidental amputation, the reamputated hand turned out to contain practically all of the remaining contamination. ... The medical management of an injured and contaminated patient in this case required at least about two person-days of professional dedication of a medical-health physics team already experienced with accidents involving external and internal contamination with americium-plutonium mixtures; this input was in addition to collaboration with a number of other physicians and medical and health physics technicians. The average medical institution likely to receive contaminated victims of a terrorist attack will not have such personnel or equipment resources. Any expectation of a medical capacity for triage and management of such patients requires prior training and equipping of personnel in each medical institution for the simplest counting and spectrometric measurements, and ready-made methods of data interpretation.
[Brodsky, A., et al; Chapter 20 in Public Protection from Nuclear, Chemical, and Biological Terrorism p 353-7. Medical Physics Publishing, Madison, Wisconsin (2004) ]**PEER REVIEWED**

/EPIDEMIOLOGY STUDIES/ A major study was performed on all 14,319 workers (11,635 men) employed at the Sellafield fuel reprocessing plant of British Nuclear Fuels between 1947 and 1975 ... The mortality of these workers was studied up to the end of 1992, and cancer incidence was examined from 1971 through 1986. The study included 5,203 workers who were monitored for exposure to plutonium, of whom 4,609 were assessed for dose. The body burden of most workers was estimated to be < 50 Bq, and only a few had > 1 kBq. ... (In this cohort, the average cumulative doses from plutonium were 712 mSv to bone surfaces, 194 mSv to lung, 91 mSv to liver, and 58 mSv to red bone marrow ... ). The number of deaths /and death rates/ from all cancers in plutonium workers is not excessive ... . The numbers of deaths from cancers of the liver, lung, and bone were not in excess, but there were significant excesses of deaths among plutonium workers when compared with the rates in England and Wales from cancer of the pleura (SMR, 4.71; p < 0.001), breast cancer (SMR, 2.36; p < 0.05) and cancers of ill-defined and secondary sites (SMR, 1.44; p < 0.05). /Plutonium, NOS/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 188-91 (2001)]**PEER REVIEWED**

/EPIDEMIOLOGY STUDIES/ Deaths among 5,413 workers employed at the Rocky Flats, Colorado, nuclear weapons facility were investigated in order to estimate the risks from exposure to plutonium and external radiation. The cohort consisted of all white men who had been employed at this facility for at least two years between the beginning of operations in 1952 and 1979. In comparison with death rates for the USA, significantly fewer deaths from all causes, all cancers, lung cancer, circulatory system diseases and accidents, poisonings and violence were observed. .... No bone tumors occurred in this cohort. A significant excess of benign and unspecified neoplasms was found; all seven cases were intracranial tumors. In a case-control study of the brain tumors at Rocky Flats, no statistically significant association was found with exposure to either external radiation or plutonium ... . /Plutonium, NOS/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 193-4 (2001)]**PEER REVIEWED**

/EPIDEMIOLOGY STUDIES/ A cohort study was conducted through 1990 of deaths among 15,727 white men who had been employed by the Los Alamos National Laboratory during 1943-77. ... For 303 plutonium-exposed workers, defined as persons with internal deposition of plutonium > 74 Bq, in comparison with 3,472 unexposed workers monitored for plutonium (< 74 Bq) ... the rate ratios for deaths from all causes and all cancers were close to 1.0. No statistically significant increases or deficits in rate ratios were observed. The rate ratio for lung cancer (eight cases in plutonium-exposed persons) was 1.78 (95% CI, 0.79-3.99). One case of osteogenic sarcoma was observed among the plutonium-exposed workers. /Plutonium, NOS/
[IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V78 194 (2001)]**PEER REVIEWED**

/EPIDEMIOLOGY STUDIES/ Prompted by a case of lung fibrosis in a retired plutonium worker, /the authors/ tested the hypothesis that plutonium inhalation increases the risk for developing chest radiograph abnormalities consistent with pulmonary fibrosis. /The authors/ conducted a retrospective study of nuclear weapons workers that included estimating absorbed doses to the lung with an internal dosimetry model. /The/ study population consisted of 326 plutonium-exposed workers with absorbed lung doses from 0 to 28 Sv and 194 unexposed workers. ...The severity of chest radiograph interstitial abnormalities /were compared/ between the two groups using the International Labour Organization profusion scoring system. There was a significantly higher proportion of abnormal profusion scores among plutonium-exposed workers (17.5%) than among unexposed workers (7.2%), P < 0.01. Lung doses of 10 Sv or greater conferred a 5.3-fold risk (95% CI 1.2-23.4) of having an abnormal chest X ray consistent with pulmonary fibrosis when compared with unexposed individuals after controlling for the effects of age, smoking and asbestos exposure. This study shows that plutonium may cause lung fibrosis in humans at absorbed lung doses above 10 Sv. /Plutonium, NOS/
[Newman LS et al; Radiat Res 164 (2): 123-31(2005) ]**PEER REVIEWED** PubMed Abstract

/EPIDEMIOLOGY STUDIES/ The authors conducted a nested case-control study of the association between lung cancer mortality and cumulative internal lung doses among a cohort of workers employed at the Rocky Flats /Plutonium/ Plant in Colorado from 1951 to 1989. Cases (n = 180) were individually matched with controls (n = 720) on age, sex, and birth year. Annual doses to the lung from plutonium, americium, and uranium isotopes were calculated for each worker with an internal dosimetry model. Lung cancer risk was elevated among workers with cumulative internal lung doses of more than 400 mSv in several different analytical models. The dose-response relation was not consistent at high doses. Restricting analysis to those employed for 15-25 years produced a statistically significant linear trend with dose (chi-square = 67.2, p < 0.001), suggesting a strong healthy worker survivor effect. The association between age at first internal lung dose and lung cancer mortality was statistically significant (odds ratio = 1.05, 95% confidence interval: 1.01, 1.10). No associations were found between lung cancer mortality and cumulative external penetrating radiation dose or cumulative exposures to asbestos, beryllium, hexavalent chromium, or nickel. /Plutonium, NOS/
[Brown SC et al; Am J Epidemiol 160 (2): 163-72 (2004) ]**PEER REVIEWED** PubMed Abstract

/EPIDEMIOLOGY STUDIES/ A cohort of about 21,000 Russian nuclear workers who worked at the Mayak plutonium production complex between 1948 and 1972 is under study. The Mayak complex, which is located in the Chelyabinsk region of the Russian Federation, includes three main plants; a reactor complex, a radiochemical separation plant, and a plutonium production plant. Workers at all three plants had potential for exposure to external radiation, and workers at the radiochemical and plutonium production plants also had potential for exposure to plutonium. Recently, data on workers at two auxiliary plants, who had much less potential for exposure, have been added to the cohort under study to expand the comparison group. As is the case for other nuclear worker cohorts, estimates of annual external doses are available from individual film badge monitoring data. Some workers were also monitored for plutonium exposure; however, since routine testing based on large urine samples did not begin until about 1970, only about 40% of workers with potential for such exposure have been monitored. External exposure and exposure to plutonium for Mayak workers far exceed those of other nuclear worker cohorts discussed previously... . For example, for the nearly 11,000 monitored workers hired before 1959, the mean cumulative external dose was 1.2 Gy, more than an order of magnitude higher than any of the cohorts described /previously/... . Analyses focused on leukemia (excluding chronic lymphocytic leukemia); cancers of the lung, liver, and bone (analyzed as a group); and solid cancers excluding lung, liver, and bone cancers (also analyzed as a group). The lung, liver and bone are the organs that receive the largest doses from plutonium, and excess cancers in all three organs have been clearly linked to plutonium exposure among Mayak workers. Analyses were adjusted for internal exposure from plutonium by using the estimated body burden for workers who had plutonium-monitoring data and by using a plutonium surrogate variable for workers who were not monitored for plutonium. The plutonium surrogate variable was recently developed from detailed work histories. For leukemia, the estimated /excess risk ratio/ (ERR)/Gy was 6.9 (90% CI 2.9, 15) for the period 3-5 years after exposure and 0.5 (90% CI 0.1, 1.1) for the period 5 or more years after exposure. The estimate based on the entire period was 1.0 (90% CI 0.5, 2.0). There were no statistically significant departures from linearity and no evidence of modification by sex or age at hire. Estimates for the solid cancer endpoints are /as follows:/ lung, liver or bone (linear model) ERR/Sv 0.30 (90% CI 0.18, 0.46); other solid cancers (linear model) ERR/Sv 0.08 (90% CI 0.03, 0.14); all solid cancers (linear model) ERR/Sv 0.15 (90% CI 0.09, 0.20); lung, liver, or bone (linear-quadratic model) ERR/Sv 0.54 (90% CI 0.27, 0.89); other solid cancers (linear-quadratic model) ERR/Sv 0.21 (90% CI 0.06, 0.37); all solid cancers (linear-quadratic model) ERR/Sv 0.30 (90% CI 0.18, 0.43). /from table/ /Plutonium, NOS/
[NAS/BRER; Health Risks from Exposure to Low Levels of Ionizing Radiation BEIR VII- Phase 2. p. 357 (2005) ]**PEER REVIEWED**

/EPIDEMIOLOGY STUDIES/ Cases of lung cancer among Mayak workers who were exposed to plutonium were described ... . The incidence in workers who received cumulative doses of external gamma-radiation higher than those permissible at the time (most received doses > 100 roentgen (about 1 Gy) and > 0.02 uCi [740 Bq] plutonium to the lung) 20 years after the beginning of exposure was significantly higher than that in workers exposed to the same types of radiation within permissible dose limits or in those who had never worked at Mayak. Since that time, three epidemiological studies have been conducted ... a cohort study by the epidemiology department, a cohort study by the internal dosimetry laboratory, and a case-control study by the clinical department. These studies are based on partially overlapping material. ... In the study by the epidemiology department, mortality ... from lung cancer was analyzed only for workers who were hired during the first decade of operations at Mayak (1948-58) ... . The number of lung cancer deaths observed in the cohort was 105, and the expected numbers calculated from national statistics and for the internal control group were 42.18 and 40.67, respectively. The risk for lung cancer increased with the total dose of alpha-particles to the lung ... /and/ no association was detected between death from lung cancer and the whole-body dose of gamma-radiation. A significantly elevated rate of mortality from lung cancer over the national average was ... /also/ reported ... among 666 women hired at the radiochemical and plutonium production plant in 1948-58. ... The number of observed cases (15) was significantly higher than that expected (2.57), and the risk for cancer mortality was associated with the total dose of alpha-radiation to the lung. Most of the deaths occurred among workers with the highest equivalent dose of alpha particles to the lung (> 100 Sv). ... Another cohort study was conducted at the ... internal dosimetry laboratory ... /and/ 80 lung cancer deaths /were reported/, while 48.17 were expected (31.83 excess deaths). All the excess deaths were concentrated in the dose category > 4.0 Sv ... . The results of the case-control study of lung cancer in Mayak workers conducted at the ... clinical department ... /which identified/ 11 potential risk factors /with/ six significant ones. One was plutonium deposition in body. ... /Examination of the distribution of lung cancers by lobe in 131 male workers at Mayak and in 178 men who had never worked at Mayak ... /found/ ... the lung cancers in the study subjects were located in the lower lobe more frequently (45%) than in ... the control groups (25%), although the lung content of plutonium is higher in the upper lobe of the lung. Mayak workers (168 cases: 154 men, 14 women) /were compared with/ ... unexposed population controls (157 control cases: 144 men, 13 women) ... the percentage of adenocarcinomas was higher in the workers (46%) than in the unexposed population (33%), and the highest percentage of adenocarcinomas (74%) was found among workers with plutonium